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ANTI-VIRAL PEPTIDE NANOCOMPLEXES (APN) FOR TREATMENT OF HIV/HCV CO-INFECTION

ANTI-VIRAL PEPTIDE NANOCOMPLEXES (APN) FOR TREATMENT OF HIV/HCV CO-INFECTION
用于治疗 HIV/HCV 混合感染的抗病毒肽纳米复合物 (APN)
批准号:
8167881
负责人:
LARISA Y POLUEKTOVA
金额:
$22.53万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Solubilization of highly hydrophobic drugs with carriers that are non-toxic, non-immunogenic and well defined remains a major obstacle in pharmaceutical sciences. Well-defined amphiphilic di- and triblock copolymers based on poly(2-oxazolines) were prepared and used for the solubilization of Paclitaxel (PTX) and other water-insoluble drugs. Probing the polymer micelles in water with the fluorescence probe pyrene, an unusual high polar microenvironment of the probe was observed. This coincides with an extraordinary large loading capacity for PTX of 45 wt.% active drug in the formulation as well as high water solubility of the resulting formulation. Physicochemical properties of the formulations, ease of preparation and stability upon lyophilization, low toxicity and immunogenicity suggest that poly(2-oxazoline)s are promising candidates for the delivery of highly challenging drugs. Furthermore, we demonstrate that PTX is fully active and provides superior tumor inhibition as compared to the commercial micellar formulation.
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ANTI-VIRAL PEPTIDE NANOCOMPLEXES (APN) FOR TREATMENT OF HIV/HCV CO-INFECTION
IMMUNE MODULATION AND RESTORATION IN HIV-1 INFECTION
  • 批准号:
    7959386
  • 项目类别:
  • 资助金额:
    $6.69万
  • 财政年份:
    2009
  • 负责人:
    LARISA Y POLUEKTOVA
  • 依托单位:
SUBTYPE C HIV VACCINE TESTING IN HUMANIZED MICE
  • 批准号:
    7719943
  • 项目类别:
  • 资助金额:
    $28.4万
  • 财政年份:
    2008
  • 负责人:
    LARISA Y POLUEKTOVA
  • 依托单位:
SUBTYPE C HIV VACCINE TESTING IN HUMANIZED MICE
  • 批准号:
    7609835
  • 项目类别:
  • 资助金额:
    $27.51万
  • 财政年份:
    2007
  • 负责人:
    LARISA Y POLUEKTOVA
  • 依托单位:
海外基金