SUBTYPE C HIV VACCINE TESTING IN HUMANIZED MICE

C 亚型 HIV 疫苗在人源化小鼠中的测试

基本信息

  • 批准号:
    7719943
  • 负责人:
  • 金额:
    $ 28.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-05-01 至 2009-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A significant obstacle in the development of an effective preventive vaccine for HIV-1 rests in the absence of a suitable animal model. To this end, humanized mice were generated by reconstitution of newborn Balb/c-Rag2-/-gc-/- mice with human hematopoietic stem cells. Animals were vaccinated with recombinant Adenovirus serotype 5 vectors (rAd5) encoding two derivatives of the HIV-1 clade C envelope proteins (gp145DCFI and gp140DCFI). After a prime-boost rAd5:gp145 immunization, significant cytokine (predominantly IFN-g) and humoral immune responses to both rAd5 and subtype C gp120 were observed. Vaccination with rAd5:gp140 followed by challenge with CCR5-utilizing clade C HIV-1C1157 resulted in the generation of virus-specific antibodies. Notably, vaccination and subsequent HIV-1 challenge induced rapid depletion of na¿ve CD4+ and effector CD8+ cells from lymphoid tissue of vaccinated humanized mice compared to non-vaccinated controls. The work demonstrates that a human immune system can function in a murine environment. The study also suggests the need for careful monitoring of breakthrough infections in HIV-1 vaccine recipients. We concluded that immunization of humanized mice with adenoviral vector encoding HIV-1 envelope protein induces specific immune responses but not viral protection.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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LARISA Y POLUEKTOVA其他文献

LARISA Y POLUEKTOVA的其他文献

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{{ truncateString('LARISA Y POLUEKTOVA', 18)}}的其他基金

ANTI-VIRAL PEPTIDE NANOCOMPLEXES (APN) FOR TREATMENT OF HIV/HCV CO-INFECTION
用于治疗 HIV/HCV 混合感染的抗病毒肽纳米复合物 (APN)
  • 批准号:
    8360243
  • 财政年份:
    2011
  • 资助金额:
    $ 28.4万
  • 项目类别:
ANTI-VIRAL PEPTIDE NANOCOMPLEXES (APN) FOR TREATMENT OF HIV/HCV CO-INFECTION
用于治疗 HIV/HCV 混合感染的抗病毒肽纳米复合物 (APN)
  • 批准号:
    8167881
  • 财政年份:
    2010
  • 资助金额:
    $ 28.4万
  • 项目类别:
IMMUNE MODULATION AND RESTORATION IN HIV-1 INFECTION
HIV-1 感染中的免疫调节和恢复
  • 批准号:
    7959386
  • 财政年份:
    2009
  • 资助金额:
    $ 28.4万
  • 项目类别:
Humanized mice for Neuro AIDS
神经艾滋病人源化小鼠
  • 批准号:
    7472578
  • 财政年份:
    2007
  • 资助金额:
    $ 28.4万
  • 项目类别:
SUBTYPE C HIV VACCINE TESTING IN HUMANIZED MICE
C 亚型 HIV 疫苗在人源化小鼠中的测试
  • 批准号:
    7609835
  • 财政年份:
    2007
  • 资助金额:
    $ 28.4万
  • 项目类别:
Humanized mice for Neuro AIDS
神经艾滋病人源化小鼠
  • 批准号:
    7339210
  • 财政年份:
    2007
  • 资助金额:
    $ 28.4万
  • 项目类别:
SIV, IDO, and the Host Response in neuroAIDS
SIV、IDO 和神经艾滋病中的宿主反应
  • 批准号:
    7746470
  • 财政年份:
    2006
  • 资助金额:
    $ 28.4万
  • 项目类别:
NEURODEGENERATION AND NEURORESTITUTION IN MURINE HIV-1 ENCEPHALITIS
小鼠 HIV-1 脑炎的神经变性和神经恢复
  • 批准号:
    7381203
  • 财政年份:
    2006
  • 资助金额:
    $ 28.4万
  • 项目类别:
NEURODEGENERATION/NEURORESTITUTION--HIV-1 ENCEPHALITIS
神经退行性/神经修复--HIV-1 脑炎
  • 批准号:
    7170369
  • 财政年份:
    2005
  • 资助金额:
    $ 28.4万
  • 项目类别:
NEURODEGENERATION AND NEURORESTITUTION IN MURINE HIV-1 ENCEPHALITIS
小鼠 HIV-1 脑炎的神经变性和神经修复
  • 批准号:
    7011810
  • 财政年份:
    2004
  • 资助金额:
    $ 28.4万
  • 项目类别:

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  • 财政年份:
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