Examining the relationship between psychological stress, matrix metalloproteinases and healing in diabetic foot ulcers

检查心理压力、基质金属蛋白酶与糖尿病足溃疡愈合之间的关系

• 批准号: G0800047/1
• 负责人: Karen Dawe
• 金额: $ 18.46万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800047%2F1
• 关键词: Examining; relationship; between; psychological; stress

This project aims to investigate how state of mind affects healing mechanisms in diabetic patients with long-term foot wounds. Research has shown that stress can have an effect on enzymes that are important for the normal healing of wounds. Diabetic patients are prone to foot wounds that can take months or years to heal. As diabetic patients have been shown to experience high levels of distress this project is interested in whether this distress contributes to problems with healing. We will directly measure levels of enzymes relevant to healing in the wounds and see whether this is related to how much psychological distress is reported by the patients and the levels of the stress hormone cortisol in their saliva. This may mean that our findings are able to explain how psychological factors can have an impact on physiological problems. Such a finding would be important for the type of care given to this group of patients as their mental health may be crucial to their physical health which may mean the provision of psychological help in conjunction with usual care. Such an intervention could result in improved healing rates and lower levels of distress in people with diabetes.

本项目旨在探讨心理状态如何影响长期足部创伤的糖尿病患者的愈合机制。研究表明，压力会影响对伤口正常愈合很重要的酶。糖尿病患者脚部容易受伤，需要数月或数年才能愈合。由于糖尿病患者已经被证明会经历高度的痛苦，这个项目对这种痛苦是否会导致治疗问题感兴趣。我们将直接测量与伤口愈合有关的酶的水平，看看这是否与病人报告的心理痛苦程度以及他们唾液中压力激素皮质醇的水平有关。这可能意味着我们的发现能够解释心理因素如何对生理问题产生影响。这一发现对于给予这组患者的护理类型非常重要，因为他们的心理健康可能对他们的身体健康至关重要，这可能意味着在常规护理的同时提供心理帮助。这样的干预可以提高治愈率，降低糖尿病患者的痛苦程度。