To develop therapies and a strategy for their translation to treat early lesions in multiple sclerosis
开发治疗多发性硬化症早期病变的疗法及其转化策略
基本信息
- 批准号:G0800954/1
- 负责人:
- 金额:$ 90.72万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2008
- 资助国家:英国
- 起止时间:2008 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We aim to develop a medicine to treat patients with multiple sclerosis (MS) so that permanent damage to their brain is diminished, or perhaps even prevented. MS causes inflammatory lesions within the brain and this can irreversibly damage the delicate brain tissue, either causing the nerve fibres to lose their insulating layer of myelin, or killing the nerve fibres. This damage causes the devastating symptoms, including blindness, paralysis and numbness. The reason inflammation damages the brain is not known but our evidence is that a lack of oxygen may be part of the problem. The inflamed brain may use so much oxygen that it cannot be provided fast enough by the blood. To find out, we propose to induce a small inflammatory lesion that mimics the MS lesion in part of the rat spinal cord, under general anaesthesia. The lesion is so small, and carefully placed, that the rats show no symptoms at all, but the lesion is sufficiently large to be able to see it clearly under the microscope. Rats with the lesion will be treated with one of a number of different therapies designed to reduce the damage caused by the inflammation. The efficacy of the therapy will be assessed microscopically by comparing the size and nature of the treated and untreated lesions. The treatments are based on a belief that improving oxygenation of the inflamed tissue will help it to survive the harsh conditions of the inflammation. Some treatments simply involve increasing the oxygen supply in the breathing air, while others are designed to increase the delivery of oxygen to the brain by treating the blood vessels. Other treatments attempt to protect the inflamed tissue from damaging events initiated by the shortage of oxygen. One important goal is to obtain information about the properties of the lesion using a brain scanner, as used in hospitals. The reason is that if the properties of the experimental lesion are known, brain scanning can be used to distinguish those patients with similar lesions, and then it will be possible to apply the effective therapies to the particular patients anticipated to benefit from them. At present the particular type of lesion can only be detected by microscopy, either after death, or after taking a piece of brain tissue out during an operation. If the research is successful it will result in a new and effective therapy to prevent disability in MS.
我们的目标是开发一种药物来治疗多发性硬化症(MS)患者,从而减少甚至预防对他们大脑的永久性损伤。多发性硬化症会导致大脑内的炎症性病变,这可能会不可逆地损害脆弱的脑组织,导致神经纤维失去髓鞘绝缘层,或杀死神经纤维。这种损伤会导致毁灭性的症状,包括失明,瘫痪和麻木。炎症损害大脑的原因尚不清楚,但我们的证据是缺氧可能是问题的一部分。发炎的大脑可能会消耗太多的氧气,以至于血液无法足够快地提供氧气。为了找到答案,我们建议诱导一个小的炎症病变,模仿MS病变的部分大鼠脊髓,全身麻醉。病变是如此之小,并仔细放置,大鼠没有表现出任何症状,但病变足够大,能够在显微镜下清楚地看到它。患有病变的大鼠将接受多种不同疗法中的一种治疗,这些疗法旨在减少炎症引起的损伤。通过比较治疗和未治疗病变的大小和性质,在显微镜下评估治疗的疗效。这些治疗是基于这样一种信念,即改善发炎组织的氧合将有助于它在炎症的恶劣条件下生存下来。一些治疗方法只是增加呼吸空气中的氧气供应,而另一些治疗方法则旨在通过治疗血管来增加氧气向大脑的输送。其他治疗方法试图保护发炎组织免受因缺氧引起的损伤。一个重要的目标是使用医院中使用的脑部扫描仪获得有关病变性质的信息。原因是,如果实验性病变的性质是已知的,大脑扫描可以用来区分那些有类似病变的患者,然后就有可能将有效的治疗方法应用于预期从中受益的特定患者。目前,特定类型的病变只能通过显微镜检测,要么在死亡后,要么在手术中取出一块脑组织后。如果这项研究成功,它将产生一种新的有效的治疗方法来预防MS的残疾。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kenneth Smith其他文献
The calculation of atomic collision processes
- DOI:
- 发表时间:
1971 - 期刊:
- 影响因子:1.4
- 作者:
Kenneth Smith - 通讯作者:
Kenneth Smith
From natural order to convention in silent gesture
从自然秩序到约定俗成的无声姿态
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
M. Schouwstra;Kenneth Smith;S. Kirby - 通讯作者:
S. Kirby
Is a holistic protolanguage a plausible precursor to language? A test case for a modern evolutionary linguistics
整体的原始语言是语言的合理先驱吗?
- DOI:
10.1075/is.9.1.02smi - 发表时间:
2008 - 期刊:
- 影响因子:1.5
- 作者:
Kenneth Smith - 通讯作者:
Kenneth Smith
Cumulative cultural evolution in a non-copying task in children and Guinea baboons
儿童和几内亚狒狒非复制任务中的累积文化进化
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Carmen Saldana;J. Fagot;S. Kirby;Kenneth Smith;N. Claidière - 通讯作者:
N. Claidière
The role of Gestalt principles in the acquisition of non-adjacent dependencies in linguistic and non-linguistic sequences
格式塔原理在语言和非语言序列中非相邻依赖性习得中的作用
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
J. Sturm;Kenneth Smith - 通讯作者:
Kenneth Smith
Kenneth Smith的其他文献
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{{ truncateString('Kenneth Smith', 18)}}的其他基金
InSIGHT: Integrating Statistical methods, Immunology and Genomics for Healthcare Translation
InSIGHT:整合统计方法、免疫学和基因组学进行医疗保健翻译
- 批准号:
MR/W018861/1 - 财政年份:2022
- 资助金额:
$ 90.72万 - 项目类别:
Research Grant
Supporting the Preparation of Science and Mathematics Teachers in Rural South Texas
支持德克萨斯州南部农村地区科学和数学教师的培养
- 批准号:
1758406 - 财政年份:2018
- 资助金额:
$ 90.72万 - 项目类别:
Continuing Grant
A BIOMARKER AND PATHWAY DISCOVERY PROGRAMME IN INFLAMMATORY DISEASE
炎症性疾病的生物标志物和通路发现计划
- 批准号:
MR/L019027/1 - 财政年份:2014
- 资助金额:
$ 90.72万 - 项目类别:
Research Grant
RAPID: Monitoring Deep Crustal Earthquake Sequence, Sierraville, California
RAPID:监测深部地壳地震序列,加利福尼亚州塞拉维尔
- 批准号:
1202664 - 财政年份:2012
- 资助金额:
$ 90.72万 - 项目类别:
Standard Grant
Collaborative Research: Free-drifting Icebergs as Proliferating Dispersion Sites of Iron Enrichment, Organic Carbon Production and Export in the Southern Ocean
合作研究:自由漂流冰山作为南大洋铁富集、有机碳生产和出口扩散的扩散场所
- 批准号:
0636813 - 财政年份:2007
- 资助金额:
$ 90.72万 - 项目类别:
Continuing Grant
Imaging the effects of inflammation and impulse activity on normal and demyelinated nerve tissue
成像炎症和冲动活动对正常和脱髓鞘神经组织的影响
- 批准号:
G0500814/2 - 财政年份:2007
- 资助金额:
$ 90.72万 - 项目类别:
Research Grant
Free Drifting Icebergs: Influence of Floating Islands on Pelagic Ecosystems in the Weddell Sea.
自由漂流冰山:漂浮岛屿对威德尔海中上层生态系统的影响。
- 批准号:
0650034 - 财政年份:2006
- 资助金额:
$ 90.72万 - 项目类别:
Continuing Grant
An autonomous bottom-transecting instrument for making long time-series measurements of phytopigment fluorescence and acoustically detectable sediment structure to abyssal depths
一种自主底部横断仪器,用于对深海植物色素荧光和声学可检测沉积物结构进行长时间序列测量
- 批准号:
0638505 - 财政年份:2006
- 资助金额:
$ 90.72万 - 项目类别:
Continuing Grant
Imaging the effects of inflammation and impulse activity on normal and demyelinated nerve tissue
成像炎症和冲动活动对正常和脱髓鞘神经组织的影响
- 批准号:
G0500814/1 - 财政年份:2006
- 资助金额:
$ 90.72万 - 项目类别:
Research Grant
Free Drifting Icebergs: Influence of Floating Islands on Pelagic Ecosystems in the Weddell Sea.
自由漂流冰山:漂浮岛屿对威德尔海中上层生态系统的影响。
- 批准号:
0529815 - 财政年份:2005
- 资助金额:
$ 90.72万 - 项目类别:
Continuing Grant
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