Characterising the D-Galactosamine Rat Model of Hepatorenal Syndrome

D-半乳糖胺肝肾综合征大鼠模型的表征

• 批准号: G0800971/1
• 负责人: Kevin Moore
• 金额: $ 51.91万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800971%2F1
• 关键词: Characterising; Galactosamine; Rat; Model; Hepatorenal

Patients with liver failure, caused by virus infection, alcohol or their daily medicines often develop acute kidney failure (hepatorenal syndrome). We are not sure how or why this occurs, but it is caused by a marked decrease of blood flow to the kidneys, itself caused by a reduction in the effectiveness of the heart to beat blood around the body, an opening up of blood vessels that supply the intestines, and increased production of a series of compounds which reduce kidney blood flow further. We appear to have a good animal model of this syndrome, but it needs further characterisation and direct comparison to patients with acute or acute on chronic liver failure who develop the hepatorenal syndrome. The aim of this study is to test the hypothesis that this animal model of acute liver and kidney failure is representative of the human disease. The second part of the study will determine some mechanisms by which we can improve kidney function in this animal model and hopefully use to treat patients with the hepatorenal syndrome.

由病毒感染、酒精或日常药物引起的肝功能衰竭患者经常发展为急性肾衰竭（肝肾综合征）。我们不确定这是如何发生的，也不知道为什么会发生，但它是由流向肾脏的血液明显减少引起的，这本身是由心脏在身体周围循环血液的有效性降低引起的，供应肠道的血管打开，以及一系列化合物的产生增加，这些化合物进一步减少了肾脏的血液流动。我们似乎有一个很好的这种综合征的动物模型，但它需要进一步的特征和直接比较急性或急性慢性肝功能衰竭患者谁发展肝肾综合征。本研究的目的是验证这种急性肝肾衰竭的动物模型能代表人类疾病的假设。研究的第二部分将确定一些机制，通过这些机制，我们可以改善动物模型的肾功能，并有望用于治疗肝肾综合征患者。