The effect of resolvin D1 on D-galactosamine-primed endotoxin shock model in mice.

溶血素是一类由二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)衍生的强效抗炎脂质介体。DHA在生理上是由15-和5-脂氧合酶催化氧化产生的。然而，目前尚不清楚RvD1对内毒素休克是否具有保护作用。本研究采用D-氨基半乳糖诱导的内毒素休克模型，观察了RvD1对炎性介质的影响，以阐明RvD1在感染性休克中的作用。

Resolvins are a family of potent anti-inflammatory lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. However, it has been unclear whether RvD1 exhibits protective action in endotoxic shock. In this study, to elucidate the effect of RvD1 on septic shock, we investigated the effect of RvD1 on inflammatory mediators, using D-galactosamine-primed endotoxin shock model.