The effect of resolvin D1 on D-galactosamine-primed endotoxin shock model in mice.

分解蛋白是一类有效的抗炎脂质介质，来源于二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）。Resolvin D1 （RvD1）是由15-和5-脂氧合酶对DHA的连续氧合产生的。然而，RvD1是否在内源性休克中表现出保护作用尚不清楚。本研究为阐明RvD1在脓毒性休克中的作用，采用d -半乳糖胺内毒素休克模型，研究RvD1对炎症介质的影响。

Resolvins are a family of potent anti-inflammatory lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. However, it has been unclear whether RvD1 exhibits protective action in endotoxic shock. In this study, to elucidate the effect of RvD1 on septic shock, we investigated the effect of RvD1 on inflammatory mediators, using D-galactosamine-primed endotoxin shock model.