Subarachnoid haemorrhage as a valid model for stroke

蛛网膜下腔出血作为中风的有效模型

• 批准号: G0801040/1
• 负责人: Stuart Allan
• 金额: $ 79.88万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801040%2F1
• 关键词: Subarachnoid; haemorrhage; valid; model; stroke

The devastating effects of a stroke are caused most commonly by a blood clot which blocks a blood vessel that supplies the brain. Blood flow is essential for normal brain function and stopping the blood supply, even for a few minutes, can cause damage and death of brain cells and the patient. We know a great deal about what happens to the brain during a stroke, but it has been very difficult to develop new treatments that are effective for patients. This is partly because stroke patients are not easy to study. We believe that we can get important information about stroke and related brain diseases, and perhaps develop new treatments, by studying a related condition called subarachnoid haemorrhage.In subarachnoid haemorrhage a blood vessel in the brain bursts rather than clots (as in stroke). We know that subarachnoid haemorrhage probably damages brain cells in a similar way to stroke, and now want to determine if the brain bleeding condition can be used to study stroke and to develop new drugs. We will do this by studying established animal models of stroke and subarachnoid haemorrhage, and patients with stroke and subarachnoid haemorrhage. Our research will involve imaging the brain and studying molecules in the blood, which we know are related to whether the patients will do well or not so well. We wish to test whether similar changes in the levels of these molecules occur in the blood of the animal models and patients, and also if stroke patients show changes similar to subarachnoid haemorrhage patients. We will also monitor how much brain damage occurs in both the animals and patients to see whether it is related to any changes in the molecules in the blood. If we see similar changes between animals and patients then this shows that subarachnoid haemorrhage patients can be used to study stroke and to test new treatments.

中风的破坏性影响最常见的原因是血液凝块阻塞了供应大脑的血管。血液流动对于正常的大脑功能是必不可少的，停止血液供应，即使是几分钟，也会导致脑细胞和患者的损伤和死亡。我们知道中风期间大脑会发生什么，但开发对患者有效的新疗法一直是非常困难的。这在一定程度上是因为中风患者不容易研究。我们相信，通过研究一种被称为蛛网膜下腔出血的相关疾病，我们可以获得有关中风和相关脑部疾病的重要信息，并可能开发新的治疗方法。在蛛网膜下腔出血中，脑部的血管破裂而不是血栓(如中风)。我们知道蛛网膜下腔出血可能会以类似于中风的方式损害脑细胞，现在我们想确定脑出血状况是否可以用于研究中风和开发新药。我们将通过研究已建立的中风和蛛网膜下腔出血的动物模型，以及中风和蛛网膜下腔出血的患者来做到这一点。我们的研究将包括对大脑进行成像和研究血液中的分子，我们知道这些分子与患者的病情好坏有关。我们希望测试这些分子的水平是否在动物模型和患者的血液中发生类似的变化，以及中风患者是否表现出与蛛网膜下腔出血患者类似的变化。我们还将监测动物和患者的大脑损伤程度，看看是否与血液中分子的任何变化有关。如果我们在动物和患者之间看到类似的变化，那么这表明蛛网膜下腔出血患者可以用于研究中风和测试新的治疗方法。