Investigating plasma membrane regulation during embryonic development

研究胚胎发育过程中的质膜调节

基本信息

  • 批准号:
    8064382
  • 负责人:
  • 金额:
    $ 13.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-05-15 至 2013-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The plasma membrane plays a central role in cytokinesis and polarity, yet we know very little about how it is regulated and maintained during embryonic development. In addition, how the association between the plasma membrane and underlying cytoskeleton is dynamically transformed during the cell cycle is unclear. The plasma membrane-associated protein, dynamin has an essential yet undefined role in cytokinesis and polarity. In recent years, considerable progress has been made demonstrating that dynamin regulates a variety of membrane-cytoskeletal events. While it is evident that dynamin may regulate and even link membrane to the cytoskeleton, it is still entirely unclear how dynamin coordinates and maintains these essential events during development. The long-term goal is to better understand how the plasma membrane is regulated and maintained during embryonic development. The objective of this research program is to define and identify factors that regulate membrane-cytoskeletal events that occur during cytokinesis and polarity and to determine how dynamin coordinate these processes. The central hypothesis of the proposal is that dynamin functions to temporally and spatially control cytokinesis machinery and influence embryonic polarity. Guided by published and strong preliminary data, we plan to test our central hypothesis and accomplish the objective of this application by pursuing the following three aims: 1) Characterize the role of dynamin during cytokinesis in animal cells; and 2) Determine the contribution of dynamin during polarity maintenance; and 3) Identify and characterize cell-cycle factors critical for membrane remodeling and maintenance during embryonic development. The proposed work is innovative, because it capitalizes on a new means of identifying and characterizing the function of distinct plasma membrane domains that are highly regulated during the cell cycle. The proposed research is significant, because it is expected that the results will fundamentally advance the fields of cytokinesis, polarity as well as membrane biology. Relevance to Public Health: Understanding how the plasma membrane is regulated and maintained during development is of utmost interest because the identified factors are anticipated to provide new targets for preventive and therapeutic interventions that will aid in the growing numbers of persons who have cancer, developmental disorders and age-related abnormalities. (End of Abstract)
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Ahna Renee Skop其他文献

Ahna Renee Skop的其他文献

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{{ truncateString('Ahna Renee Skop', 18)}}的其他基金

Functional analysis of mammalian midbody RNA in post-mitotic signaling functions
哺乳动物中间体 RNA 在有丝分裂后信号传导功能中的功能分析
  • 批准号:
    10297652
  • 财政年份:
    2021
  • 资助金额:
    $ 13.64万
  • 项目类别:
Functional analysis of mammalian midbody RNA in post-mitotic signaling functions
哺乳动物中间体 RNA 在有丝分裂后信号传导功能中的功能分析
  • 批准号:
    10684068
  • 财政年份:
    2021
  • 资助金额:
    $ 13.64万
  • 项目类别:
METAPHASE SPINDLE PROTEOME
中期纺锤体蛋白质组
  • 批准号:
    8365842
  • 财政年份:
    2011
  • 资助金额:
    $ 13.64万
  • 项目类别:
METAPHASE SPINDLE PROTEOME
中期纺锤体蛋白质组
  • 批准号:
    8171229
  • 财政年份:
    2010
  • 资助金额:
    $ 13.64万
  • 项目类别:
METAPHASE SPINDLE PROTEOME
中期纺锤体蛋白质组
  • 批准号:
    7957790
  • 财政年份:
    2009
  • 资助金额:
    $ 13.64万
  • 项目类别:
Investigating plasma membrane regulation during embryonic development
研究胚胎发育过程中的质膜调节
  • 批准号:
    8255641
  • 财政年份:
    2008
  • 资助金额:
    $ 13.64万
  • 项目类别:
Investigating plasma membrane regulation during embryonic development
研究胚胎发育过程中的质膜调节
  • 批准号:
    7474136
  • 财政年份:
    2008
  • 资助金额:
    $ 13.64万
  • 项目类别:
Investigating plasma membrane regulation during embryonic development
研究胚胎发育过程中的质膜调节
  • 批准号:
    7620415
  • 财政年份:
    2008
  • 资助金额:
    $ 13.64万
  • 项目类别:
Investigating plasma membrane regulation during embryonic development
研究胚胎发育过程中的质膜调节
  • 批准号:
    7842615
  • 财政年份:
    2008
  • 资助金额:
    $ 13.64万
  • 项目类别:
METAPHASE SPINDLE PROTEOME
中期纺锤体蛋白质组
  • 批准号:
    7723625
  • 财政年份:
    2008
  • 资助金额:
    $ 13.64万
  • 项目类别:

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