The role of SNAREs in post-Golgi trafficking.

点击翻译按钮获取中文摘要

The inside of a cell is organized into a series of compartments (organelles) with each organelle having a defined function. Once a protein has been made or modified in one organelle, its function or activity is often required somewhere else. The cell therefore has to transport the protein to the site where it is needed, this is accomplished by packaging the proteins into a small lipid bound packages (vesicles) that brake off from one organelle and fuse with another. The aim of my research is to understand how these vesicles know with which organelles they should fuse. This research will increase our fundamental understanding of how cells function and may give insight into how defects in these processes cause diseases.