Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 7942615
• 负责人: Bernhard H. Weigl
• 金额: $ 4万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942615
• 关键词: Address; Cessation of life; Clinical; Collaborations; Developed Countries; Developing Countries; Development; Diagnostic; Diagnostic tests; Drug Prescriptions; Drug resistance; Emerging Technologies; Engineering; Generations; Goals; Health; Healthcare; International; Laboratories; Lead; Legal; Manuals; Needs Assessment; Patients; Play; Private Sector; Procedures; Process; Public Health; Research; Research Personnel; Resources; Role; Scientist; Staging; Technology; Testing; Training; Training Programs; Underserved Population; Universities; Washington; Work; base; design; experience; improved; innovation; pandemic disease; point of care; point-of-care diagnostics; product development; prototype; research clinical testing

DESCRIPTION (provided by applicant): The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

描述（由申请人提供）： 使用适当的床旁（POC）诊断测试可能意味着正确的 在低资源环境（LRS）中，特别是在发展中国家，诊断能力最低、不足或不存在。专为LRS设计的新型和创新性POC诊断技术将对全球公共卫生产生重大影响：提供及时和适当的患者治疗，减少药物过度处方，抑制耐药性的传播，并对潜在的大流行性疾病发出早期警报。新兴的诊断技术为解决LRS中许多临床未满足的需求提供了机会。 PATH是开发负担得起和适当的诊断测试的国际领导者， 合作伙伴正在提议建立一个全球健康护理诊断中心（中心）。在五年的时间里，该中心将通过以下方式加快对LRS至关重要的POC诊断测试的开发和部署：对多达五种选定的原型POC诊断测试进行基于实验室和现场的临床评估（核心1）;确定并选择多达四种创新和有前途的技术作为潜在的POC诊断测试（核心2）;在相关资源有限的环境中对与POC诊断相关的关键临床需求进行评估（核心3）;提供严格的培训计划，以教育技术开发人员和研究人员，科学家和工程师，包括那些来自私营部门的公司，最后，通过一个强有力的综合管理团队并在所需的机构支持（技术、设施、行政、财务、法律的和后勤）下协调各项活动（核心5）。通过为所有核心的活动提供培训和编写手册、教程和标准作业程序，以及制定严格的传播需求评估和研究的计划，该中心将在其五年期之后产生影响。 该中心由PATH管理，并与华盛顿大学全球卫生部合作，作为培训核心的领导者，将在加速开发和引入POC使用的诊断测试方面发挥核心作用。PATH在产品开发、现场测试和引入过程的各个阶段与公共和私营部门合作伙伴合作的独特而广泛的经验，以及华盛顿大学在LRS培训方面的经验，为该项目的最终目标提供了理想的支持：通过增加基本POC诊断测试的可用性、可及性和可负担性，改善全球服务不足人群的健康。