Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 8181158
• 负责人: Bernhard H. Weigl
• 金额: $ 11.29万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181158
• 关键词: Acute; Address; Affect; Biotechnology; Cessation of life; Clinic; Clinical; Collaborations; Communicable Diseases; Communities; Community Health; Complex; Country; Developed Countries; Developing Countries; Development; Diagnosis; Diagnostic; Diagnostic tests; Diarrhea; Disease; Drug Prescriptions; Drug resistance; Emerging Technologies; Engineering; Evaluation; Fever; Generations; Goals; Health; Health Services; Health system; Healthcare; Homelessness; Income; Indian reservation; Individual; Industry; Institution; International; Intervention; Investments; Knowledge; Laboratories; Lead; Legal; Life; Low Income Population; Manuals; Marketing; Migrant Workers; Monitor; Names; National Institute of Biomedical Imaging and Bioengineering; Nature; Needs Assessment; Patients; Play; Population; Preventive; Private Sector; Procedures; Process; Provider; Public Health; Public Sector; Publishing; Recording of previous events; Recurrence; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Science; Scientist; Series; Solutions; Staging; Symptoms; System; Technology; Testing; Therapeutic; Training; Training Programs; Underserved Population; Universities; Vaginal Discharge; Washington; Work; Writing; base; care seeking; cost; design; experience; global health; improved; innovation; intervention effect; intervention program; neglect; novel strategies; outreach; pandemic disease; point of care; point-of-care diagnostics; product development; programs; prototype; research clinical testing; tool

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的护理点 (POC) 诊断测试可能意味着正确治疗与持续患病或死亡之间的差异：在资源匮乏地区 (LRS)，特别是在发展中国家，诊断能力很少、不足或不存在。专为 LRS 设计的新型创新 POC 诊断技术将通过以下方式对全球公共卫生产生重大影响：提供及时和适当的患者治疗、减少过度处方药物、抑制耐药性的传播以及对潜在大流行性疾病发出早期警报。诊断领域的新兴技术为解决 LRS 中许多临床未满足的需求提供了机会。 PATH 是开发负担得起且适当的诊断测试的国际领导者，其合作伙伴正在提议建立一个全球健康护理点诊断推进中心（以下简称“中心”）。在五年内，该中心将通过以下方式加速 LRS 必需的 POC 诊断测试的开发和部署： 对最多五个选定的原型 POC 诊断测试（核心 1）进行实验室和现场临床评估；识别和选择最多四种创新且有前途的技术作为 POC 诊断测试的潜在开发（核心 2）；在相关资源有限的环境中对与 POC 诊断相关的关键临床需求进行评估（核心 3）；提供严格的培训计划，以教育技术开发人员和研究人员、科学家和工程师，包括来自私营部门公司的人员，了解在 LRS 中提供医疗保健的现实（核心 4）；最后，通过强大的综合管理团队和所需的机构支持（技术、设施、行政、财务、法律和后勤）协调活动（核心 5）。通过培训和制定所有核心活动的手册、教程和标准操作程序，以及传播需求评估和研究的严格计划，该中心将在其五年期限后产生影响。 该中心由 PATH 管理，并与作为培训核心牵头的华盛顿大学 (UW) 全球健康系合作，将在加速开发和引入用于 POC 的诊断测试方面发挥核心作用。 PATH 在产品开发、现场测试和引进过程的各个阶段与公共和私营部门合作伙伴合作的独特而丰富的经验，加上威斯康星大学在 LRS 培训方面的经验，为该项目的最终目标提供了理想的支持：通过提高基本 POC 诊断测试的可用性、可及性和可负担性来改善全球服务不足人群的健康。

项目成果

A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen.

• DOI: 10.1109/tbme.2010.2087334
• 发表时间: 2011-03
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Barfield CA;Barney RS;Crudder CH;Wilmoth JL;Stevens DS;Mora-Garcia S;Yanovsky MJ;Weigl BH;Yanovsky J
• 通讯作者: Yanovsky J

Field evaluation of a prototype paper-based point-of-care fingerstick transaminase test.

• DOI: 10.1371/journal.pone.0075616
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Pollock NR;McGray S;Colby DJ;Noubary F;Nguyen H;Nguyen TA;Khormaee S;Jain S;Hawkins K;Kumar S;Rolland JP;Beattie PD;Chau NV;Quang VM;Barfield C;Tietje K;Steele M;Weigl BH
• 通讯作者: Weigl BH

Purification of DNA/RNA in a microfluidic device.

微流体装置中 DNA/RNA 的纯化。

• DOI: 10.1007/978-1-62703-134-9_25
• 发表时间: 2013
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Fan,Andy;Byrnes,Samantha;Klapperich,Catherine
• 通讯作者: Klapperich,Catherine

The NIBIB Point of Care Technologies Research Network Center Themes and Opportunities for Exploratory POC Projects.

NIBIB 护理点技术研究网络中心探索性 POC 项目的主题和机会。

• DOI: 10.1097/poc.0b013e318162f3dd
• 发表时间: 2008
• 期刊: Point of care
• 作者: Kost,GeraldJ;Korte,Brenda;BeyetteJr,FredR;Gaydos,Charlotte;Weigl,Bernhard
• 通讯作者: Weigl,Bernhard

Towards non- and minimally instrumented, microfluidics-based diagnostic devices.

• DOI: 10.1039/b811314a
• 发表时间: 2008-12
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Weigl B;Domingo G;Labarre P;Gerlach J
• 通讯作者: Gerlach J