Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 7688789
• 负责人: Bernhard H. Weigl
• 金额: $ 24.19万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688789
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Address; Advanced Development; Affect; Agency for International Development; Biomedical Engineering; Biomedical Research; Biotechnology; Caring; Cessation of life; Clinic; Clinical; Collaborations; Communicable Diseases; Communities; Community Health; Complex; Condition; Country; Daily; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Diarrhea; Disease; Drug Prescriptions; Drug resistance; Effectiveness of Interventions; Emerging Technologies; Engineering; Environment; Evaluation; Feedback; Fever; Foundations; Future; Generations; Goals; Government; Health; Health Services; Health Technology; Health system; Healthcare; Homelessness; Income; Indian reservation; Individual; Industry; Institutes; Institution; International; Intervention; Investments; Kenya; Knowledge; Laboratories; Lead; Legal; Life; Low Income Population; Manuals; Marketing; Medical; Medicine; Methods; Mission; Monitor; Names; Nature; Needs Assessment; Outcome; Patients; Performance; Play; Population; Prevalence; Preventive; Private Sector; Procedures; Process; Provider; Public Health; Public Sector; Publishing; Recording of previous events; Recurrence; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resources; Role; Science; Scientist; Series; Site; Solutions; Staging; Standards of Weights and Measures; Symptoms; System; Technology; Testing; Therapeutic; Time; Training; Training Programs; Tropical Disease; Underserved Population; Universities; Vaginal Discharge; Washington; Work; World Health Organization; Writing; base; bioimaging; care seeking; commercialization; cost; design; evaluation/testing; experience; improved; innovation; intervention program; neglect; novel diagnostics; novel strategies; outreach; pandemic disease; performance tests; point of care; programs; prototype; research and development; research clinical testing; tool; usability

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的护理点 (POC) 诊断测试可能意味着正确的诊断测试之间的差异 治疗或持续患病或死亡：在资源匮乏地区（LRS），特别是在发展中国家， 诊断能力极小、不足或不存在。新型创新 POC 诊断 专为 LRS 设计的技术将通过以下方式对全球公共卫生产生重大影响： 及时、恰当地治疗患者，减少过量用药，抑制药物传播 抵抗力并提高对潜在流行性疾病的早期警报。诊断领域的新兴技术 提供了解决 LRS 中许多临床未满足需求的机会。 PATH 是开发负担得起且适当的诊断测试的国际领导者，其 合作伙伴正在提议建立一个全球健康护理点诊断推进中心（以下简称“中心”）。超过 五年内，中心将加速POC诊断测试的开发和部署 对 LRS 至关重要的方法是： 对最多 5 个选定项目进行实验室和现场临床评估 原型 POC 诊断测试（核心 1）；识别和选择最多四个创新且有前途的 作为 POC 诊断测试的潜在开发技术（核心 2）；进行评估 在相关资源有限的环境中与 POC 诊断相关的关键临床需求（核心 3）；提供一个 严格的培训计划来教育技术开发人员和研究人员、科学家和工程师， 包括私营部门公司的人员，了解 LRS 中提供医疗保健的现实（核心 4）；和 最后，通过强大的综合管理团队和所需的协调活动 机构支持（技术、设施、行政、财务、法律和后勤）（核心 5）。通过 培训并生成所有活动的手册、教程和标准操作程序 核心，以及传播需求评估和研究的严格计划，该中心将拥有一个 影响超过其五年期限。 由 PATH 管理，与华盛顿大学 (UW) 全球健康系合作 作为培训核心的龙头，中心将在加快发展和建设中发挥核心作用。 引入用于 POC 的诊断测试。 PATH 独特而丰富的合作经验 产品开发、现场测试和推出各个阶段的公共和私营部门合作伙伴 流程以及威斯康星大学在 LRS 培训方面的经验，为该项目的实施提供了理想的支持 最终目标：通过增加可用性来改善全世界服务不足人群的健康， 基本 POC 诊断测试的可及性和可负担性。