Training in Translational Breast Cancer Research

描述（申请人提供）：乳腺癌是女性中最常见的癌症，占美国癌症诊断的三分之一。根除乳腺癌可能需要不同科学学科之间的伙伴关系和培训新一代的基础和转化研究人员。该培训基金的目标是培养6名博士后（包括医学博士和博士），在激素调节、信号转导、细胞周期控制、细胞结构和运动以及乳腺癌实验治疗方面进行最先进的研究。拟议拨款的优势在于培训教员。来自基础科学部门和临床部门（包括布拉曼家族乳腺癌研究所和西尔维斯特综合癌症中心）的13名教职员工是一个优秀的团队，他们的研究包括结构，分子和细胞生物学，基础和转化科学方法的交叉部分，用于乳腺癌研究。教师在培养研究生和博士后（包括医学博士/博士）成为成功的独立研究人员方面具有丰富的经验。该计划的总体目标是为学员提供指导，使他们获得独特的研究技能，并培养他们的智力严谨性，以维持独立的、临床知情的乳腺癌研究事业。所有受训者都必须参加正式的教学课程、专题讨论会、乳腺癌研究研讨会、大型会议、讲习班、期刊俱乐部和年度务静会，这些活动为不同学科之间的思想交流和互动提供了论坛。受训人员的研究进展将在每两周的数据审查中密切监测。因此，该培训项目满足了国家对具有丰富基础、临床和转化研究知识的乳腺癌研究人员的迫切需求。该计划有许多独特的优势，包括：1)一个专门的乳腺癌研究机构（布拉曼家族乳腺癌研究所）和一个知名的癌症中心（西尔维斯特综合癌症中心）的存在；2)研究生产力、研究经费、培训经验、项目教师的管理能力和经验，特别是项目主任；3)促进乳腺癌临床和基础研究之间持续互动的基础设施的机会和可用性。

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among women, accounting for one third of cancer diagnosis in the United States. Eradication of breast cancer is likely to require a partnership of diverse scientific disciplines and training of new breed of basic and translational researchers. The goal of this training grant is to train 6 postdoctoral fellows (including MD and PhD) to perform state-of-the-art research in hormonal regulation, signal transduction, cell cycle controls, cell structure and motility, and experimental therapeutics applied to breast cancer. The strength of the proposed grant is the training faculty. Drawn from both basic science departments and clinical departments (including Braman Family Breast Cancer Institute and Sylvester Comprehensive Cancer Center), the 13 faculty members are an excellent group whose well-funded research comprises a cross-section of structural, molecular and cell biological, basic and translational science approaches to breast cancer research. The faculty members have extensive experience in training graduate students and postdoctoral fellows (including MD/PhD) who have gone onto become successful independent researchers. The overall goal of this program is to provide guidance for trainees to acquire unique research skills and to mold their intellectual rigor to sustain an independent, clinically-informed research career in breast cancer. All trainees are required to attend formal didactic courses, symposia, breast cancer research seminars, grand rounds, workshops, journal clubs and an annual retreat, which provide forum for exchange of ideas and interaction among different disciplines. Progress of the trainee's research will be closely monitored in bi-weekly data reviews. Thus this training program fulfills a serious national need for breast cancer researchers with ample knowledge in basic, clinical and translational research. The proposed program has many unique strengths including : 1) the existence of a specialized breast cancer research institute (Braman Family Breast Cancer Institute) and a well-known cancer center (Sylvester Comprehensive Cancer Center), 2) the research productivity, research funding, training experience, and administrative capability and experience of program faculty in general and the program directors in particular, and 3) the opportunity and availability of infrastructure for fostering continued interactions between clinical and basic research in breast cancer.