New Synthetic Methods for Anticancer Research

抗癌研究的新合成方法

• 批准号: 6571687
• 负责人: LANNY S LIEBESKIND
• 金额: $ 28.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-20 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6571687
• 关键词: antineoplastics; chemical addition; chemical bond; chemical structure function; chemical substitution; chemical synthesis; drug discovery /isolation; heavy metals; method development; nickel; organic chemicals; palladium; sulfur compounds; thioether; thiols

DESCRIPTION (provided by applicant): As a foundation upon which new medicinal agents can be constructed, it is important to uncover simple, yet powerful methods for the synthesis of core organic functionalities, as well as methods that allow the core structures to be easily substituted with a wide variety of substituents. It is in support of health sciences in general that the chemistry proposed within finds its significance. Because of the unique ability of transition metal species to effect the formation of carbon-carbon and carbon-heteroatom bonds under very mild conditions, emphasis in this proposal is placed on the use of organotransition metal chemistry to facilitate a variety of transformations. An underlying theme of the proposed chemistry is the development of flexible new synthetic methods that will facilitate the structure-activity-relationship studies that lead to the discovery of new medicinal agents.

描述（由申请人提供）：作为可以构建新药物的基础，重要的是发现简单但有效的核心有机官能团合成方法，以及允许核心结构容易地被各种取代基取代的方法。它是在支持健康科学一般的化学提出内发现其意义。由于过渡金属物质在非常温和的条件下影响碳-碳和碳-杂原子键的形成的独特能力，本提案的重点放在使用有机过渡金属化学来促进各种转化上。所提出的化学的一个基本主题是开发灵活的新合成方法，这将促进结构-活性-关系研究，从而发现新的药物。