New Synthetic Methods for Anticancer Research

抗癌研究的新合成方法

• 批准号: 6834570
• 负责人: LANNY S LIEBESKIND
• 金额: $ 26.21万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-20 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834570
• 关键词: New; Synthetic; Methods; Anticancer; Research

EXCEED THE SPACE PROVIDED. Ayest apofowuenrfdualtionmethuopdosn wfohricthe nseywnthmeseidsicinoafl coaregenotrsganciacn fbuencctionsatlriutiectse,d, asit wiselilmpaosrtmanetthotdos untchoavteralloswimptlhee, core structures to be easily substituted with a wide variety of substituents. It is in support of health sciences in general that the chemistry proposed within finds its significance. Because of the unique ability of transition metal species to effect the formation of carbon-carbon and carbon-heteroatom bonds under very mild conditions, emphasis in this proposal is placed on the use of organotransition metal chemistry to facilitate a variety of transformations. An underlying theme of the )roposed chemistry is the development of flexible new synthetic methods that will facilitate the structure-activity-relationship studies that lead to the discovery of new medicinal agents. PERFORMANCE SITE(S) (organization, city, state) Emory University Department of Chemistry 1515 Pierce Drive Atlanta, Georgia 30322 KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Liebeskind, Lanny S. Emory University Srogl, Jiri Emory University Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01) Page 2 Number pages consecutively at the bottom throughout the application. Do no._u_sLet suffixessuch as 3a, 3b. format shown below. Role on Project Principal Investigator St. Research Associate Form Page 2 ========================================Section End===========================================

超出所提供的空间。尽管这种双重方法可以有效地将这些化合物转化为结构，但是，尽管这种方法可以选择性地使核心结构容易地被各种各样的取代基取代。它是在支持健康科学一般的化学提出内发现其意义。由于过渡金属物质在非常温和的条件下影响碳-碳和碳-杂原子键的形成的独特能力，本提案的重点放在使用有机过渡金属化学来促进各种转化上。定向化学的一个基本主题是开发灵活的新合成方法，这将促进导致发现新药物的结构-活性-关系研究。执行地点（组织、城市、州）埃默里大学化学系，地址：1515 Pierce Drive Atlanta，格鲁吉亚30322关键人员。参见说明。根据需要使用续页，以提供与主要研究者开始时所需的信息。按字母顺序列出所有其他关键人员，姓在前。名称组织Liebeskind，Lanny S.埃默里大学Srogl，Jiri埃默里大学披露许可声明。仅适用于SBIR/STTR。参见说明。[]是[]否PHS 398（修订版05/01）第2页在整个申请的底部连续编号页。不要。_ u_sLet后缀，如3a、3b。格式如下。项目主要研究者St.研究助理表第2页上的角色=