New Synthetic Methods for Anticancer Research

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EXCEED THE SPACE PROVIDED. Ayest apofowuenrfdualtionmethuopdosn wfohricthe nseywnthmeseidsicinoafl coaregenotrsganciacn fbuencctionsatlriutiectse,d, asit wiselilmpaosrtmanetthotdos untchoavteralloswimptlhee, core structures to be easily substituted with a wide variety of substituents. It is in support of health sciences in general that the chemistry proposed within finds its significance. Because of the unique ability of transition metal species to effect the formation of carbon-carbon and carbon-heteroatom bonds under very mild conditions, emphasis in this proposal is placed on the use of organotransition metal chemistry to facilitate a variety of transformations. An underlying theme of the )roposed chemistry is the development of flexible new synthetic methods that will facilitate the structure-activity-relationship studies that lead to the discovery of new medicinal agents. PERFORMANCE SITE(S) (organization, city, state) Emory University Department of Chemistry 1515 Pierce Drive Atlanta, Georgia 30322 KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Liebeskind, Lanny S. Emory University Srogl, Jiri Emory University Disclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] No PHS 398 (Rev. 05/01) Page 2 Number pages consecutively at the bottom throughout the application. Do no._u_sLet suffixessuch as 3a, 3b. format shown below. Role on Project Principal Investigator St. Research Associate Form Page 2 ========================================Section End===========================================