New Synthetic Methods for Anticancer Research

描述(由申请人提供)：作为构建新药物的基础，重要的是发现合成核心有机官能团的简单而有效的方法，以及允许核心结构容易地被各种取代基取代的方法。正是在总体上支持健康科学，里面提出的化学找到了它的意义。由于过渡金属物种在非常温和的条件下影响碳-碳和碳-杂原子键的形成的独特能力，本提议的重点是使用有机过渡金属化学来促进各种转化。拟议化学的一个基本主题是开发灵活的新合成方法，这些方法将促进结构-活性-关系研究，从而发现新的药剂。

DESCRIPTION (provided by applicant): As a foundation upon which new medicinal agents can be constructed, it is important to uncover simple, yet powerful methods for the synthesis of core organic functionalities, as well as methods that allow the core structures to be easily substituted with a wide variety of substituents. It is in support of health sciences in general that the chemistry proposed within finds its significance. Because of the unique ability of transition metal species to effect the formation of carbon-carbon and carbon-heteroatom bonds under very mild conditions, emphasis in this proposal is placed on the use of organotransition metal chemistry to facilitate a variety of transformations. An underlying theme of the proposed chemistry is the development of flexible new synthetic methods that will facilitate the structure-activity-relationship studies that lead to the discovery of new medicinal agents.