New Synthetic Methods for Anticancer Research

描述（由申请人提供）：作为构建新药物的基础，重要的是发现简单而强大的核心有机官能团合成方法，以及允许核心结构容易被各种取代基取代的方法。它是在支持健康科学一般，化学提出了它的意义。由于过渡金属具有在非常温和的条件下影响碳-碳和碳杂原子键形成的独特能力，因此本提案的重点是利用有机过渡金属化学来促进各种转化。提出的化学的潜在主题是灵活的新合成方法的发展，这将促进结构-活性-关系的研究，从而发现新的药物制剂。

DESCRIPTION (provided by applicant): As a foundation upon which new medicinal agents can be constructed, it is important to uncover simple, yet powerful methods for the synthesis of core organic functionalities, as well as methods that allow the core structures to be easily substituted with a wide variety of substituents. It is in support of health sciences in general that the chemistry proposed within finds its significance. Because of the unique ability of transition metal species to effect the formation of carbon-carbon and carbon-heteroatom bonds under very mild conditions, emphasis in this proposal is placed on the use of organotransition metal chemistry to facilitate a variety of transformations. An underlying theme of the proposed chemistry is the development of flexible new synthetic methods that will facilitate the structure-activity-relationship studies that lead to the discovery of new medicinal agents.