Creating A Biomarker Registry for Secondary Data Collections

描述（由申请人提供）：本申请要求R21探索性基金开发方法和工具，以实现在公开的二级数据收集中发现的生物标志物和健康变量的全面登记。拟议的试验开始时，将从国家老龄问题计算机化数据档案馆和大学间社会和政治科学联合会所收集的数据中提取数据。我们将利用这个基础来建立协议，以审查和识别其他收集的变量，这些变量测量通常被称为生物标志物的生物和医学指标，使我们能够创建一个全面的注册表，供公众使用。越来越多的变量定义为生物标志物定期收集作为许多调查的一部分，这一应用程序是第一次提出一个有效的方法来组织这个不断增长的宇宙的信息到一个注册系统，并促进使用这些数据进行二次研究。第一年提出的评估和鉴定过程将建立一个框架，在第二年，将建立一个广泛的系统，以纳入NACDA和我们现有档案库之外保存的数据收集的生物标志物信息。 项目叙述： 这项工作涉及研究数据的组织，以提供关于健康的生物和医学指标的信息。该项目将帮助研究人员开发原创性研究，研究医学测试，肥胖和其他健康因素对个人生活的影响。

DESCRIPTION (provided by applicant): This application requests R21 exploratory funds to develop methodology and tools leading to a comprehensive registry of biomarker and health variables found in publicly available secondary data collections. The proposed pilot will begin with data drawn from collections maintained by the National Archive of Computerized Data on Aging (NACDA) and the Inter-University Consortium of Social and Political Science (ICPSR). We will use this base to establish protocols to review and identify variables in other collections that measure biological and medical indicators commonly referred to as biomarkers allowing us to create a comprehensive registry of such indicators for public use. Increasingly variables defined as biomarkers are routinely collected as part of many surveys; this application is the first to propose an effective approach for organizing this growing universe of information into a registry system and to promote the use of these data for secondary research. The evaluation and identification process proposed for year one will establish a framework that, in the second year, will establish a broad system to incorporate biomarker information from data collections maintained both within NACDA and outside our established archives. Project Narrative: This work addresses the organization of research data to provide access to and information on biological and medical indicators of health. The project will help researchers develop original research that studies the impacts of medical tests, obesity and other health factors on the lives of individuals.