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The Biology of Resilience: Oxytocin, Social Relationships and Health

复原力的生物学：催产素、社会关系和健康

基本信息

批准号：
7758708
负责人：
LAURA D KUBZANSKY
金额：
$ 16.45万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-01-15 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7758708
关键词：
Address Adult Affect Age Aging Animals Applications Grants Area Biological Biology Blood Pressure Buffers Cardiac Output Cardiovascular system Child Communities Development Disease Distress Double-Blind Method Elderly Estrogens Exploratory/Developmental Grant for Diagnostic Cancer Imaging Frequencies Gender Goals Growth Health Hormones Human Hydrocortisone Investigation Laboratories Lactation Life Life Cycle Stages Literature Longevity Measures Molecular Mothers Neurobiology Neurosecretory Systems Outcome Outcome Measure Oxytocin Participant Pathway interactions Pattern Personal Satisfaction Phenotype Physiological Physiological Adaptation Placebo Control Placebos Play Posterior Pituitary Hormones Preventive Intervention Procedures Process Randomized Recruitment Activity Research Research Personnel Research Project Grants Resources Role Sampling Social Interaction Social support Solid Stress System Testing Time Vascular resistance Woman Work biobehavior dehydroepiandrosterone early life exposure emotional experience emotional factor experience heart rate variability insight interdisciplinary approach men multidisciplinary novel programs protective effect psychologic public health relevance reproductive research study resilience response social social attachment social stress stress management theories young adult

项目摘要

DESCRIPTION (provided by applicant): This is a second revised application for an exploratory/developmental research grant award (R21). Positive social relationships have consistently been associated with better health, although the neurobiological underpinnings of these observed effects are not well understood. Valuable insight may be gained by a life course perspective as it is becoming increasingly apparent that early life social experiences are crucially related to later life functioning and well-being. The overall goal of the proposed work is to explore novel biological pathways that may help to explain how social relationships influence health throughout the life course. Oxytocin is a neurohypophyseal hormone hypothesized to coordinate both the causes and effects of positive social interactions, and may be involved in positive physiological adaptations such as buffering the deleterious effects of stress. The proposed research will examine whether and how oxytocin influences responses to stress in humans and will consider these effects in relation to those of social support. More specifically, experimental research will be used to determine whether exogenously administered oxytocin (intranasal) influences psychological and physiological outcomes under conditions of stress across gender and age in adulthood. Hypotheses to be tested are: 1) Oxytocin ameliorates the deleterious neuroendocrine, cardiovascular, and subjective effects of stress; 2) Oxytocin and social support have similar and additive stress-buffering effects; 3) Effects of oxytocin are stronger in women versus men; 4) Effects of oxytocin are similar across a range of both younger and older adult ages. Hypotheses will be tested with a placebo-controlled double blind study using a sample of healthy men and women recruited from the community. Participants will be randomly assigned to receive either oxytocin or placebo. They will undergo a social stress manipulation with and without social support (randomly assigned), and outcome measures will be obtained at multiple times during the procedure. The proposed research represents a novel area of investigation by a multidisciplinary team of investigators. This work will provide a solid platform from which to launch a larger program of research aimed at identifying how positive social and emotional experiences influence adult health and longevity. Ultimately, a more neurobiological understanding of resilience can inform efforts for prevention and intervention of diseases or problems common in later life. PUBLIC HEALTH RELEVANCE: The proposed work has the potential to provide new insight into the biological mechanisms underlying the protective effects of positive social relationships on health. This experimental study utilizes a multidisciplinary approach focusing on the interplay between molecular, psychological, and social processes as they relate to aging, and will provide a solid platform from which to launch a larger program of research. Ultimately, a neurobiological understanding of resilience may inform efforts for both prevention and intervention of diseases or problems common in later life.

描述（由申请人提供）：这是探索性/发展性研究补助金（R21）的第二次修订申请。积极的社会关系一直与更好的健康有关，尽管这些观察到的影响的神经生物学基础还没有得到很好的理解。有价值的洞察力可以通过生命历程的角度来获得，因为它变得越来越明显，早期生活的社会经验与以后的生活功能和福祉至关重要。这项工作的总体目标是探索新的生物学途径，这可能有助于解释社会关系如何影响整个生命过程中的健康。催产素是一种神经垂体激素，被假设为协调积极社会互动的原因和影响，并且可能参与积极的生理适应，例如缓冲压力的有害影响。这项拟议中的研究将研究催产素是否以及如何影响人类对压力的反应，并将考虑这些影响与社会支持的影响。更具体地说，实验研究将用于确定外源性催产素（鼻内）是否会影响成年期不同性别和年龄的压力条件下的心理和生理结果。待检验的假设为：1）催产素改善有害的神经内分泌，心血管和主观压力的影响; 2）催产素和社会支持具有相似的和附加的压力缓冲作用; 3）催产素的作用在女性中比男性更强; 4）催产素的作用在年轻和老年人的年龄范围内相似。将使用从社区招募的健康男性和女性样本，通过安慰剂对照双盲研究对假设进行检验。参与者将被随机分配接受催产素或安慰剂。他们将在有和没有社会支持的情况下接受社会压力操纵（随机分配），并将在手术期间多次获得结局指标。拟议的研究代表了多学科研究团队的一个新的研究领域。这项工作将提供一个坚实的平台，从中启动一个更大的研究计划，旨在确定积极的社会和情感体验如何影响成年人的健康和寿命。最终，对韧性的神经生物学理解可以为预防和干预晚年常见疾病或问题的努力提供信息。公共卫生相关性：这项工作有可能为积极的社会关系对健康的保护作用的生物学机制提供新的见解。这项实验性研究采用了多学科方法，重点关注与衰老相关的分子，心理和社会过程之间的相互作用，并将为启动更大的研究计划提供坚实的平台。最终，对复原力的神经生物学理解可以为预防和干预晚年常见疾病或问题的努力提供信息。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A heartfelt response: Oxytocin effects on response to social stress in men and women.

DOI：
10.1016/j.biopsycho.2012.02.010
发表时间：
2012-04
期刊：
BIOLOGICAL PSYCHOLOGY
影响因子：
2.6
作者：
Kubzansky, Laura D.;Mendes, Wendy Berry;Appleton, Allison A.;Block, Jason;Adler, Gail K.
通讯作者：
Adler, Gail K.

Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender.