Growth Hormone and Cardiovascular Disease

生长激素与心血管疾病

• 批准号: 7893329
• 负责人: Karen K Miller
• 金额: $ 19.83万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-20 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893329
• 关键词: Acute; Adipose tissue; Alteplase; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Center for Translational Science Activities; Central obesity; Chronic; Clinical; Clinical Investigator; Clinical Research; Developed Countries; Development; Discipline; Dose; Endocrine; Ensure; Environment; Faculty; Fatty acid glycerol esters; Fellowship Program; Fibrinogen; Funding; Gender; General Hospitals; Goals; Grant; Hormones; Insulin; Insulin Resistance; Leadership; Lipids; Lipoprotein (a); Lipoproteins; Massachusetts; Medial; Mediating; Medicine; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Obesity; Public Health; Recombinants; Relative (related person); Research; Research Personnel; Risk Marker; Role; Skeletal Muscle; Somatotropin; Source; Thick; Time; Training; United States National Institutes of Health; Vasodilation; Visceral; Woman; abdominal fat; base; cardiovascular risk factor; career; career development; growth hormone deficiency; intrahepatic; medical schools; men; muscle form; patient oriented; programs; success

DESCRIPTION (provided by applicant): The scientific goal of this proposal is to investigate the effects of relative growth hormone deficiency and replacement on body composition and cardiovascular risk markers in men and women with abdominal obesity. The career development goal of this application is to support the candidate's professional development as a clinical investigator and successful mentor for fellows and junior faculty in patient-oriented clinical research by providing sufficient time for research and mentoring activities. The mentoring goal of this application is to facilitate the training of fellows and junior faculty in clinical research to form the basis of independent careers. The candidate's NHLBI-funded R01 grant investigating the effects of growth hormone replacement on body composition and cardiovascular risk markers in viscerally adipose men and women with relative growth hormone deficiency will form the basis for the training plan of the grant. Additional research opportunities are available in the form of ongoing studies that are funded by a number of other sources. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and other disciplines. The Institutional environment at the MGH, with a strong and diverse Medicine Department, Clinical Translational Science Center grant through Harvard Medical School, and Clinical Research Program, is outstanding. The Department of Medicine at the MGH has made a substantial commitment, including 90% protected time and dedicated space, toward the candidate's development as a clinical researcher responsible for training fellows and junior faculty. The Midcareer Investigator Award in Patient Oriented Research is an ideal mechanism to ensure the necessary support to reduce clinical and administrative responsibilities, and ensure the candidate's continued success as a mentor and clinical researcher. Project Narrative: Cardiovascular disease is the leading cause of death and illness in developed countries. This proposal investigates the role of low growth hormone levels as a possible hormone mechanism underlying the increased cardiovascular risk in women and men with abdominal adiposity and thus could have significant public health implications.

描述（由申请人提供）：该提案的科学目标是研究相对生长激素缺乏和替代对腹部肥胖男性和女性的身体成分和心血管风险标志物的影响。该应用程序的职业发展目标是通过提供足够的时间进行研究和指导活动，支持候选人作为临床研究者的专业发展，以及以患者为导向的临床研究中研究员和初级教师的成功导师。该应用程序的指导目标是促进临床研究研究员和初级教师的培训，为独立职业奠定基础。该候选人的 NHLBI 资助的 R01 拨款研究了生长激素替代对生长激素相对缺乏的内脏脂肪男性和女性的身体成分和心血管风险标志物的影响，这将构成该拨款培训计划的基础。其他研究机会以正在进行的研究的形式提供，这些研究由许多其他来源资助。该候选人拥有在国家级指导方面的领导记录，以及在马萨诸塞州总医院 (MGH) 内分泌奖学金计划和其他学科指导学员的成功记录。麻省总医院的机构环境非常出色，拥有强大而多元化的医学系、哈佛医学院资助的临床转化科学中心以及临床研究项目。 MGH 医学系做出了重大承诺，包括 90% 的受保护时间和专用空间，以帮助候选人发展成为负责培训研究员和初级教员的临床研究员。以患者为导向的研究中的职业生涯中期研究员奖是一种理想的机制，可确保提供必要的支持，减少临床和行政责任，并确保候选人作为导师和临床研究人员持续取得成功。 项目叙述：心血管疾病是发达国家死亡和疾病的主要原因。该提案调查了低生长激素水平作为导致腹部肥胖的女性和男性心血管风险增加的可能激素机制的作用，因此可能对公共健康产生重大影响。