Growth Hormone and Cardiovascular Disease

描述（由申请人提供）：本提案的科学目标是研究相对生长激素缺乏和替代对腹部肥胖男性和女性身体成分和心血管危险标志物的影响。该申请的职业发展目标是通过提供足够的研究和指导活动时间，支持候选人作为临床研究者和在以患者为导向的临床研究中成功指导研究员和初级教员的专业发展。这项申请的指导目标是促进临床研究方面的研究员和初级教员的培训，为独立的职业生涯奠定基础。候选人获得nhlbi资助的R01资助，研究生长激素替代对相对缺乏生长激素的内脏脂肪男性和女性的身体成分和心血管风险指标的影响，将构成该资助的培训计划的基础。更多的研究机会以正在进行的研究的形式提供，这些研究由一些其他来源资助。候选人在指导国家层面的领导记录，并在指导马萨诸塞州总医院（MGH）内分泌奖学金计划和其他学科的学员方面取得了成功的记录。MGH的机构环境非常出色，拥有强大而多样化的医学部、由哈佛医学院资助的临床转化科学中心和临床研究项目。MGH的医学部已经做出了实质性的承诺，包括90%的保护时间和专用空间，用于候选人作为临床研究员的发展，负责培训研究员和初级教员。面向患者研究的职业中期研究者奖是一个理想的机制，以确保必要的支持，以减少临床和行政责任，并确保候选人作为导师和临床研究者的持续成功。

DESCRIPTION (provided by applicant): The scientific goal of this proposal is to investigate the effects of relative growth hormone deficiency and replacement on body composition and cardiovascular risk markers in men and women with abdominal obesity. The career development goal of this application is to support the candidate's professional development as a clinical investigator and successful mentor for fellows and junior faculty in patient-oriented clinical research by providing sufficient time for research and mentoring activities. The mentoring goal of this application is to facilitate the training of fellows and junior faculty in clinical research to form the basis of independent careers. The candidate's NHLBI-funded R01 grant investigating the effects of growth hormone replacement on body composition and cardiovascular risk markers in viscerally adipose men and women with relative growth hormone deficiency will form the basis for the training plan of the grant. Additional research opportunities are available in the form of ongoing studies that are funded by a number of other sources. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and other disciplines. The Institutional environment at the MGH, with a strong and diverse Medicine Department, Clinical Translational Science Center grant through Harvard Medical School, and Clinical Research Program, is outstanding. The Department of Medicine at the MGH has made a substantial commitment, including 90% protected time and dedicated space, toward the candidate's development as a clinical researcher responsible for training fellows and junior faculty. The Midcareer Investigator Award in Patient Oriented Research is an ideal mechanism to ensure the necessary support to reduce clinical and administrative responsibilities, and ensure the candidate's continued success as a mentor and clinical researcher.