Growth Hormone and Cardiovascular Disease

生长激素与心血管疾病

• 批准号: 9090179
• 负责人: Karen K Miller
• 金额: $ 12.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-20 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9090179
• 关键词: Adipocytes; Affect; Aging; Apolipoproteins B; Blood; Body Composition; Bone Density; Bone Marrow; Bone Marrow Stem Cell; C-reactive protein; Cardiovascular Diseases; Center for Translational Science Activities; Clinical; Clinical Research; Complication; Data; Deposition; Development; Dose; Educational process of instructing; Endocrine; Ensure; Environment; Epidemic; Faculty; Fatty acid glycerol esters; Fellowship Program; Finite Element Analysis; Fracture; Funding; General Hospitals; Goals; Grant; Health; Homeostasis; Hormones; Individual; Inflammatory; Insulin; Insulin-Like Growth Factor I; Lead; Leadership; Lipids; Lipoproteins; Liver; Magnetic Resonance Spectroscopy; Maintenance; Massachusetts; Mediating; Mediator of activation protein; Medicine; Menopause; Mentors; Mentorship; Mesenchymal; Midcareer Investigator Award in Patient-Oriented Research; Muscle; N.I.H. Research Support; Normal Range; Obesity; Osteoblasts; Osteocalcin; Osteogenesis; Osteoporosis; Pathway interactions; Pharmaceutical Preparations; Physiological; Physiology; Pituitary Gland; Play; Protocols documentation; Publishing; Qualifying; Regulation; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Serum; Skeleton; Somatotropin; Techniques; Thick; Time; Training; United States National Institutes of Health; Vitamin D; Vitamin D2; Weight; Woman; abdominal fat; base; bone; bone health; bone loss; bone mass; bone strength; career; career development; cytokine; growth hormone deficiency; improved; interest; lean body mass; medical schools; member; men; mid-career faculty; muscle form; new therapeutic target; novel; novel therapeutics; osteoblast differentiation; patient oriented research; programs; skeletal; skills; stem cell differentiation; success; wasting

 DESCRIPTION (provided by applicant): The scientific goal of this project is to investigate the role of relative growth hormone (GH) deficiency in the etiopathology of bone loss in obese men and women, and the mechanisms by which GH may affect bone microarchitecture and strength. The candidate is an Associate Professor of Medicine at Harvard Medical School and a faculty member at Massachusetts General Hospital who is deeply committed to and highly qualified for a career in patient-oriented research and to mentor new clinician investigators. She has an outstanding record of patient-oriented research (POR) and mentoring during the first K24 grant period. The career development goal of this K24 competitive renewal application is to support the candidate's continued professional development as a POR mentor of fellows and junior faculty with her long-term goal of developing independent POR researchers. The candidate's specific short-term mentoring objectives are: 1) to attract and train new trainees, 2) assist her current mentees to obtain K and R grant funding, to develop their own POR focuses and assist with all other aspects of transitioning to independent careers focused on POR, 3) acquire additional mentoring skills and 3) continue and expand teaching in courses that reach a large number of trainees interested in pursuing POR careers. The candidate's NIH grants will form the basis of research project support for trainees. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and trainees from a number of other departments. The institutional environment is outstanding at the MGH and Harvard Medical School, with an extremely strong Department of Medicine, a Clinical Translational Science Center grant through Harvard Medical School, and a Clinical Research Program at the MGH, all of which offer a myriad of didactic opportunities, facilities and support. The Department of Medicine has made a strong commitment to the candidate, including protected time and dedicated space. The Midcareer Investigator Award in Patient-Oriented Research is an ideal mechanism to ensure the necessary support to protect time for mentorship for this outstanding mentor, who otherwise would have to increase her clinical and administrative responsibilities, and to ensure the candidate's continued success as a mentor and clinical researcher.

 描述(申请人提供)：这个项目的科学目标是研究相对生长激素(GH)缺乏在肥胖男性和女性骨丢失病因中的作用，以及GH可能影响骨微结构和强度的机制。应聘者是哈佛医学院医学副教授和马萨诸塞州综合医院的教员，他坚定地致力于以患者为导向的研究并指导新的临床医生研究人员，他具有很高的职业资格。在第一个K24资助期，她在以病人为中心的研究(POR)和指导方面有着出色的记录。这份K24竞争续签申请的职业发展目标是支持候选人作为研究员和初级教员的POR导师的持续职业发展，她的长期目标是发展独立的POR研究人员。候选人的具体短期指导目标是：1)吸引和培训新学员，2)帮助她目前的学员获得K和R资助，发展他们自己的POR重点，并协助过渡到专注于POR的独立职业的所有其他方面，3)获得更多的指导技能，3)继续和扩大课程的教学，使大量有兴趣从事POR职业的学员受益。候选人的NIH拨款将构成对受训者研究项目支持的基础。该候选人在国家层面的指导方面具有领导能力，并在指导马萨诸塞州综合医院(MGH)内分泌奖学金计划的学员和其他一些部门的学员方面取得了成功的记录。麻省理工学院和哈佛医学院的制度环境非常出色，拥有非常强大的医学系，哈佛医学院授予的临床转化科学中心拨款，以及麻省理工学院的临床研究项目，所有这些都提供了无数的教学机会、设施和支持。医学部对候选人做出了强有力的承诺，包括保护时间和专用空间。以患者为中心的研究中的职业生涯中期研究员奖是一个理想的机制，以确保获得必要的支持，以保护这位杰出导师的指导时间，否则她将不得不增加她的临床和管理责任，并确保候选人作为导师和临床研究人员继续取得成功。