Identifying the neural signature of persistent pain

慢性疼痛影响超过20%的澳大利亚人。尽管其患病率很高，但它对当前的治疗方案具有相对抵抗力，我们无法提供令人满意的疼痛缓解的部分原因是由于我们对这种情况下的病理生理学的了解有限。该提案将对与慢性疼痛相关的中枢神经可塑性变化以及这些变化在维持这些条件中所起的作用产生新的理解。

Chronic pain affects over 20% of Australians. Despite its high prevalence, it is relativly resistant to current treatment regimes and part of the reason behind our inadequate ability to provide satisfactory pain relief is due to our limited understanding of the pathophysiology that underlies this condition. This proposal will develop a novel understanding of the central neuroplastic changes associated with chronic pain and the role that these changes play in the maintenance of these conditions.