Risk for Lung Cancer, Asthma, and COPD; Integrating Clinical and Airway Biomarker

肺癌、哮喘和慢性阻塞性肺病的风险；

• 批准号: 7796405
• 负责人: SIMON D SPIVACK
• 金额: $ 16.77万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-12 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7796405
• 关键词: Address; Area; Arts; Asthma; Award; Biological Markers; Cancer Detection; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Clinical Trials Design; Collaborations; Data; Data Analyses; Data Set; Development; Dimensions; Disease; Drug Formulations; Early Diagnosis; Epidemiology; Future; Genetic; Goals; Health; Hispanics; Individual; Investments; Joints; Laboratories; Link; Lung diseases; Malignant neoplasm of lung; Medical Oncology; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Molecular; Molecular Biology; Monitor; Nursing Faculty; Population; Postdoctoral Fellow; Prevention; Prevention strategy; Public Health; Public Health Schools; Pulmonology; Research; Research Design; Research Personnel; Research Project Grants; Risk; Risk Assessment; Role; Rotation; Sampling; Series; Techniques; Time; Tissues; Touch sensation; Training; Translational Research; Universities; base; career; case control; cohort; college; disorder risk; experience; human study; interest; member; next generation; novel; oncology; patient oriented research; population based; prospective; statistics; tool; translational study

DESCRIPTION (provided by applicant): The overall goal of this K24 award proposal is to further the development of Dr. Spivack into an exceptional trans-disciplinary patient-oriented research mentor, capable of guiding trainees from developing a clinical hypothesis to formulation of a series of answerable component questions. Key components of that mentorship role will include the articulation of critical aspects of relevant human study design; invoking, where applicable, the creative procurement and analyses of relevant tissue biomarkers by collaboration with appropriate laboratory support; and engagement of sophisticated data analytic techniques to definitively address the hypotheses in a clinically-meaningful manner. The overall aim of the proposal is therefore to support this translational mentorship function. The Specific Aims are: 1) Provide protected time for the PI to further train in epidemiology and statistics, particularly with respect to accrual and analysis of multi-dimensional observational datasets, both case-control/cross-sectional, and prospective cohorts with a time dimension. This will include those studies invoking genetic data analyses, and in prevention trials design and analyses. 2) Provide clinical-translational mentorship for one to two junior clinical faculty members, and a continuous rotation of two to four Pulmonary Medicine or Medical Oncology post-doctoral clinical fellows, at any given time over the project period. 3) Initiate the assessment of prospective cohort-based clinical risk, invoking clinical and airway-specific molecular biomarker analyses of common lung diseases (lung cancer, asthma, COPD), for facilitating the development of early detection and prevention strategies. The current capacity of the Spivack laboratory to develop, sample, accrue and analyze a population, and to conceive, develop and apply state-of-art molecular methodologies for airway disease biomarker analyses to the same population, provides a very unique training opportunity for clinical and other post-doctoral trainees in Medicine, Pulmonary Medicine, Oncology, and in translational research in general. Facilitated by a K24 award, the mentoring experience will be markedly enhanced, as will a shift to evaluating existing prospective cohorts, in a trans-disciplinary manner. The research questions are fundamentally clinical: (1) Can we identify individuals at risk for lung cancer, asthma, and COPD, to facilitate early detection strategies? (2) Can we intervene in individuals, to reduce that risk, using preventive strategies?

描述（由申请人提供）：本次K24奖提案的总体目标是进一步发展Spivack博士成为一个杰出的跨学科的以患者为导向的研究导师，能够指导受训者从发展临床假设到制定一系列可回答的组成问题。该指导角色的关键组成部分将包括阐明相关人类研究设计的关键方面；在适用的情况下，通过与适当的实验室支持合作，调用相关组织生物标志物的创造性采购和分析；并采用复杂的数据分析技术，以一种具有临床意义的方式明确地解决这些假设。因此，提案的总体目标是支持这种转化指导功能。具体目标是：