Clinical Relevance of GB Virus C & Hepatitis C Virus in HIV+ Women

GB 病毒 C 的临床相关性

• 批准号: 7884585
• 负责人: JASON T BLACKARD
• 金额: $ 19.43万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-02 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7884585
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Basic Science; CD4 Lymphocyte Count; Clinical Research; Collaborations; Communicable Diseases; Data; Diagnosis; Disease; Disease Progression; Drug usage; Family; Flaviviridae; Future; GB virus; GB virus C; Gender; Gene Mutation; Genotype; HCV Liver Disease; HIV; HIV Seropositivity; Health; Hepatitis C virus; High Prevalence; High Risk Woman; Individual; Infection; Injection of therapeutic agent; Interferons; Knowledge; Laboratories; Lead; Literature; Liver; Liver diseases; Longitudinal Studies; Measures; Mediating; Morbidity - disease rate; Opportunistic Infections; Outcome; Overdose; Participant; Persons; Population; Prevalence; Prospective Studies; Publications; RNA; RNA Viruses; Receptor Gene; Relative (related person); Reporting; Resources; Role; Serological; Sex Characteristics; Substance abuse problem; Time; Treatment outcome; Universities; Vascular blood supply; Viremia; Virus; Virus Diseases; Virus Replication; Woman; Work; abstracting; antiretroviral therapy; clinically relevant; cohort; ethnic minority population; experience; human disease; in vivo; innovation; male; men; mortality; novel therapeutics; public health relevance; racial and ethnic; treatment strategy

DESCRIPTION (provided by applicant): (GBV-C) is a single-stranded RNA virus that is the closest known relative of hepatitis C virus (HCV). GBV-C has not been associated with any human disease to date. However, several studies have reported a beneficial effect of GBV-C viremia on HIV disease progression - reduced HIV RNA levels, increased CD4 cell counts, and slower disease progression - predominantly in cohorts with a high proportion of men. However, the prevalence of GBV-C differs significantly between men and women, and no large prospective studies have examined the effects of GBV-C co-infection on HIV disease progression in women. In a preliminary study, we found that GBV-C genotype 2 was associated with higher CD4 cell counts compared to genotype 1, and that GBV-C genotype 2 was more sensitive to clearance after interferon treatment than GBV-C genotype 1. Therefore, we propose to evaluate the presence of GBV-C co-infection and the role of GBV-C genotype in modulating HIV disease progression in a well-characterized cohort of women with HIV/AIDS to enhance our knowledge of GBV-C/HIV interactions. This work is significant and innovative because no large prospective studies of the role of GBV-C co-infection in modulating HIV disease have been reported in HIV positive women and because its addresses a potentially beneficial interaction between GBV-C and HIV that could be exploited in the future to develop novel therapeutic strategies. PUBLIC HEALTH RELEVANCE: To date, GB virus type C (GBV-C) has not been associated with any human disease, although several studies have reported a beneficial effect of GBV-C infection on HIV disease progression. The prevalence of GBV-C may differ by gender; however, the adventitious role of GBV-C co-infection on HIV disease, as well as the potential modulatory effects of GBV-C genotype, has not yet been evaluated in a longitudinal manner in women. Such studies could ultimately lead to novel therapeutic strategies to treat HIV disease, particularly among difficult-to-treat populations and/or individuals with limited access to antiretroviral therapy.

描述(申请人提供)：(GBV-C)是一种单链RNA病毒，是已知的丙型肝炎病毒(丙型肝炎病毒)的最近亲属。到目前为止，GBV-C还没有与任何人类疾病有关。然而，几项研究报告了GBV-C病毒血症对艾滋病毒疾病进展的有益影响--降低艾滋病毒RNA水平，增加CD4细胞计数，减缓疾病进展--主要是在男性比例较高的队列中。然而，GBV-C的患病率在男性和女性之间存在显著差异，而且还没有大型前瞻性研究检查GBV-C混合感染对女性艾滋病毒疾病进展的影响。在一项初步研究中，我们发现与基因1相比，GBV-C基因2与更高的CD4细胞计数相关，并且GBV-C基因2比基因1对干扰素治疗后的清除更敏感。因此，我们建议评估GBV-C合并感染的存在以及GBV-C基因在调节HIV疾病进展中的作用，以增强我们对GBV-C/HIV相互作用的了解。这项工作具有重大意义和创新性，因为尚未有关于GBV-C合并感染在HIV阳性妇女中调节HIV疾病的作用的大型前瞻性研究报告，而且它解决了GBV-C和HIV之间的潜在有益相互作用，未来可以利用这种相互作用来开发新的治疗策略。公共卫生相关性：到目前为止，GB病毒C型(GBV-C)尚未与任何人类疾病有关，尽管一些研究报告了GBV-C感染对艾滋病毒疾病进展的有益影响。GBV-C的患病率可能因性别不同而不同；然而，GBV-C混合感染对艾滋病毒疾病的外来作用以及GBV-C基因的潜在调节作用尚未在女性中进行纵向评估。这类研究最终可能导致治疗艾滋病毒疾病的新治疗战略，特别是在难以治疗的人群和/或获得抗逆转录病毒治疗机会有限的个人中。

项目成果

Role of GB virus C in modulating HIV disease.

GB病毒C在调节HIV疾病中的作用。

• DOI: 10.1586/eri.12.37
• 发表时间: 2012-05
• 期刊: Expert review of anti-infective therapy
• 影响因子: 5.7
• 作者: Schwarze-Zander C;Blackard JT;Rockstroh JK
• 通讯作者: Rockstroh JK

Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany.

• DOI: 10.1002/jmv.22029
• 发表时间: 2011-04
• 期刊: JOURNAL OF MEDICAL VIROLOGY
• 影响因子: 12.7
• 作者: Neibecker, Markus;Schwarze-Zander, Carolynne;Rockstroh, Juergen K.;Spengler, Ulrich;Blackard, Jason T.
• 通讯作者: Blackard, Jason T.

Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.

• DOI: 10.1002/jmv.24836
• 发表时间: 2017-11
• 期刊: Journal of medical virology
• 影响因子: 12.7
• 作者: Blackard JT;Ma G;Welge JA;Taylor LE;Mayer KH;Klein RS;Celentano DD;Sobel JD;Jamieson DJ;King CC
• 通讯作者: King CC