Prokaryotic gene regulation by light and oxygen
光和氧的原核基因调控
基本信息
- 批准号:7791282
- 负责人:
- 金额:$ 50.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-12-01 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:AerobicAffectAnabolismBacteriaBacteriochlorophyllsBindingBiochemicalBiological ModelsBlood VesselsBlood capillariesCarbonCell RespirationCell physiologyCellsChlorophyllDNA BindingDiseaseEnergy MetabolismEnzymesFermentationFundingGene ExpressionGene Expression RegulationGenesGenetic TranscriptionGoalsGrowthGrowth FactorHemeHomologous GeneHydrogenLaboratoriesLightMammalian CellMammalsMetabolicMetabolismMolecularNatureNitrogen FixationOrganismOxidation-ReductionOxygenOxygen measurement, partial pressure, arterialPathway interactionsPhosphorylationPhosphotransferasesPhotosynthesisPhysiologicalPhysiological ProcessesProcessProductionProteobacteriaRegulationRespirationRhodobacterRhodobacter capsulatusRhodobacter sphaeroidesRoleSystemTetrapyrrolesUbiquinoneVariantYeastscapillarycarbon fixationcell typecofactordiadenosine pyrophosphateheme biosynthesislight intensityresponsesensortranscription factortumor growth
项目摘要
Alteration in oxygen tension affects gene expression in all cell types. In bacterial systems, oxygen regulates
a variety of genes involved in aerobic versus anaerobic energy metabolism. Metabolic processes such as
carbon fixation, nitrogen fixation, respiration and photosynthesis are regulated in response to the presence
or absence of oxygen. In yeast and algal cells, oxygen is known to affect transcription of oxidative defense
genes as well as metabolic enzymes. In mammalian cells, a growing number of genes are known to be
oxygen regulated such as vascular growth factors that are key regulators for the synthesis of new capillary
sprouts from preexisting vessels. Besides physiological roles, these growth factors are involved in disease
processes such as the stimulation of capillary formation during tumor growth.
This proposal is centered on elucidating molecular details of how bacteria Rhodobacter capsulatus and
Rhodobacter sphaeroides are able to sense changes in oxygen tension, and in response, alter gene
expression. These related species are capable of growth in a variety of energy generating modes including
aerobic respiration, anaerobic fermentation and photosynthesis. The expression of genes involved in each
of these processes are affected by alterations in oxygen tension, as well as by variations in light intensity.
Regulation of cell physiology by light is also known to occur in a number of organisms ranging from bacterial
to mammals and is a second process that is studied by this proposal. Indeed, one of the key oxygen
regulated transcription factors studied in this proposal is also regulated by light intensity.
As a model system for studying both oxygen and light regulation of gene expression, we have focused on
the process of tetrapyrrole biosynthesis. This pathway is highly regulated by oxygen and light intensity and
is responsible for the production of such important metabolites as B12, heme and chlorophylls.
氧张力的改变会影响所有细胞类型的基因表达。在细菌系统中,氧气调节
涉及有氧与无氧能量代谢的多种基因。代谢过程如
碳固定、固氮、呼吸和光合作用根据存在而受到调节
或缺氧。在酵母和藻类细胞中,氧气会影响氧化防御的转录
基因以及代谢酶。在哺乳动物细胞中,已知越来越多的基因
氧气调节,例如血管生长因子,是新毛细血管合成的关键调节因子
从预先存在的容器中发芽。除了生理作用外,这些生长因子还与疾病有关
过程,例如肿瘤生长过程中刺激毛细血管形成。
该提案的重点是阐明细菌荚膜红杆菌和
球形红杆菌能够感知氧张力的变化,并作为响应改变基因
表达。这些相关物种能够以多种能量产生模式生长,包括
有氧呼吸、无氧发酵和光合作用。各相关基因的表达
这些过程的过程受到氧张力的变化以及光强度的变化的影响。
光对细胞生理学的调节也发生在许多生物体中,从细菌到
哺乳动物,这是该提案研究的第二个过程。事实上,关键的氧气之一
本提案中研究的调节转录因子也受光强度调节。
作为研究基因表达的氧和光调节的模型系统,我们重点关注
四吡咯生物合成过程。该途径受到氧气和光强度的高度调节
负责产生维生素 B12、血红素和叶绿素等重要代谢物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CARL Eugene BAUER其他文献
CARL Eugene BAUER的其他文献
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{{ truncateString('CARL Eugene BAUER', 18)}}的其他基金
Regulatory Circuits Controlling Development of Dormant Microbial Cysts
控制休眠微生物囊肿发育的调节电路
- 批准号:
8605881 - 财政年份:2012
- 资助金额:
$ 50.73万 - 项目类别:
Regulatory Circuits Controlling Development of Dormant Microbial Cysts
控制休眠微生物囊肿发育的调节电路
- 批准号:
8215581 - 财政年份:2012
- 资助金额:
$ 50.73万 - 项目类别:
Regulatory Circuits Controlling Development of Dormant Microbial Cysts
控制休眠微生物囊肿发育的调节电路
- 批准号:
8415958 - 财政年份:2012
- 资助金额:
$ 50.73万 - 项目类别:
Regulatory Circuits Controlling Development of Dormant Microbial Cysts
控制休眠微生物囊肿发育的调节电路
- 批准号:
8789366 - 财政年份:2012
- 资助金额:
$ 50.73万 - 项目类别:
CONTINUED HIGH RESOLUTION STRUCTURAL ANALYSIS OF APPA
APPA 的持续高分辨率结构分析
- 批准号:
7181920 - 财政年份:2005
- 资助金额:
$ 50.73万 - 项目类别:
CONTINUED HIGH RESOLUTION STRUCTURAL ANALYSIS OF APPA
APPA 的持续高分辨率结构分析
- 批准号:
6978212 - 财政年份:2004
- 资助金额:
$ 50.73万 - 项目类别:
PROKARYOTIC SWARM CELL DIFFERENTIATION & PHOTOPERCEPTION
原核群体细胞分化
- 批准号:
6019474 - 财政年份:1998
- 资助金额:
$ 50.73万 - 项目类别:
PROKARYOTIC SWARM CELL DIFFERENTIATION & PHOTOPERCEPTION
原核群体细胞分化
- 批准号:
2681474 - 财政年份:1998
- 资助金额:
$ 50.73万 - 项目类别:
PROKARYOTIC SWARM CELL DIFFERENTIATION & PHOTOPERCEPTION
原核群体细胞分化
- 批准号:
6386977 - 财政年份:1998
- 资助金额:
$ 50.73万 - 项目类别:
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