Obesity and Urinary Incontinence (OUI)

肥胖和尿失禁 (OUI)

• 批准号: 7940009
• 负责人: LESLEE L SUBAK
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940009
• 关键词: Adipocytes; Award; Body Weight decreased; Body mass index; California; Clinical; Clinical Investigator; Clinical Management; Clinical Research; Clinical and Translational Science Awards; Cohort Studies; Commit; Data; Development; Discipline; Discipline of obstetrics; Economics; Epidemiology; Faculty; Fellowship; Fellowship Program; Female; Fostering; Funding; Future; Geology; Goals; Grant; Gynecology; Incontinence; Individual; Inflammatory; Institutes; Institution; K-Series Research Career Programs; Laboratories; Leadership; Lower urinary tract; Measures; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Obesity; Outcome; Overweight; Patients; Positioning Attribute; Prevention; Productivity; Program Development; Questionnaires; Randomized Controlled Clinical Trials; Recording of previous events; Recruitment Activity; Reproductive Health; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Role; SECTM1 gene; San Francisco; Science; Staging; Time; Training; Training Programs; Translational Research; Trust; United States National Institutes of Health; Universities; Urinary Incontinence; Urology; Weight; Woman; Women' s Health; Work; bariatric surgery; base; career; career development; college; innovation; interest; lower urinary tract symptoms; member; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient oriented research; population based; professor; programs; prospective; reproductive; research study; skills

DESCRIPTION (provided by applicant): Leslee L. Subak, MD is Associate Professor of Obstetrics, Gynecology & Reproductive Sciences, Urology & Epidemiology at the University of California, San Francisco (UCSF) with an established track record as a researcher, clinician and mentor. She is Co-Program Director of the UCSF Women's Reproductive Health Research Career Development Program, Director of the UCSF/Mount Zion Women's Health Clinical Re-search Center Fellowship and on the core development team for the UCSF Clinical & Translational Sciences Institute's (CTSI) Mentor Development Program (MDP). She leads a productive patient-oriented research program with active R01's and has successfully helped launch the careers of several junior investigators. The overarching aims of the proposed research are to elucidate the mechanisms of the association between obesity and urinary incontinence (Ul) in women and facilitate the translational development of novel approaches to treatment and prevention. We will investigate the longitudinal association between body mass index (BMI) and Ul, evaluate the possible role of adipocytokines in the BMI-UI relationship and identify independent risk factors for incident Ul and progression or regression of existing Ul. Questionnaire, laboratory and outcome data from NIH-funded studies, including a randomized trial, a population-based prospective cohort study and a cohort study of bariatric surgery, will be analyzed. Dr. Subak will use her research as a platform for mentoring clinical researchers and will promote a multidisciplinary, translational research approach to Ul. She will continue to expand her ongoing mentorship of individual young investigators, be a leader in building the innovative CTSI-sponsored MDP to train the next generation of mentors and establish an integrated clinical and research fellowship program for Urology and Urogynecology at UCSF. Strengths of the candidate include her formal training in research methods, history of research productivity and NIH funding, and an early track record of mentoring junior trainees. Strengths of the institution include the resources of the CTSI and K30, several K12 training grants from which to recruit mentees, a unique formal mentor training program and the availability of resources to foster research of junior investigators. Dr. Subak has the enthusiastic support of her department, the UCSF CTSI and translational research collaborators to pursue her research goals. This award will be instrumental in advancing her innovative research on the BMI-UI association and the effect of weight loss on Ul in women, and in mentoring the "next generation" of investigators committed to patient-oriented research in urinary incontinence.

描述(由申请人提供)： Leslee L.Subak医学博士是加州大学旧金山分校(UCSF)产科、妇科和生殖科学、泌尿外科和流行病学副教授，作为研究员、临床医生和导师，有着良好的记录。她是加州大学旧金山分校女性生殖健康研究职业发展项目的联合项目主任，加州大学旧金山分校/锡安山女性健康临床研究中心奖学金项目主任，以及加州大学旧金山分校临床与翻译科学研究所(CTSI)导师发展项目(MDP)的核心开发团队成员。她与活跃的R01‘S一起领导了一个富有成效的以患者为中心的研究项目，并成功地帮助启动了几名初级调查人员的职业生涯。 这项拟议研究的主要目的是阐明肥胖与女性尿失禁(Ul)之间的联系机制，并促进新的治疗和预防方法的翻译开发。我们将调查体重指数(BMI)和UL之间的纵向关联，评估脂肪细胞因子在BMI-UI关系中的可能作用，并确定发生UL和现有UL进展或退化的独立危险因素。将分析来自NIH资助的研究的问卷、实验室和结果数据，包括一项随机试验、一项基于人群的前瞻性队列研究和一项减肥手术的队列研究。Subak博士将利用她的研究作为指导临床研究人员的平台，并将促进对Ul的多学科、转化性研究方法。她将继续扩大她对个人年轻研究人员的持续指导，在建立由CTSI赞助的创新MDP以培训下一代导师方面发挥带头作用，并在加州大学旧金山分校建立一个针对泌尿外科和泌尿外科的综合临床和研究奖学金计划。 候选人的优势包括她在研究方法、研究生产力和NIH资金方面的正式培训，以及早期指导初级学员的记录。该机构的优势包括CTSI和K30的资源，可供招募学员的几笔K12培训补助金，独特的正式导师培训计划，以及可用于促进初级调查人员研究的资源。 Subak博士得到了她所在部门、加州大学旧金山分校CTSI和翻译研究合作者的热情支持，以追求她的研究目标。这一奖项将有助于推进她对BMI-UI协会和减肥对女性尿路的影响的创新研究，并有助于指导致力于以患者为导向的尿失禁研究的“下一代”研究人员。