Patient Oriented Research and Mentoring in Obesity and Urinary Incontinence

以患者为中心的肥胖和尿失禁研究和指导

• 批准号: 9526064
• 负责人: LESLEE L SUBAK
• 金额: $ 18.6万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9526064
• 关键词: Affect; Award; Body Weight Changes; Body Weight decreased; Clinical Research Curriculum Award; Clinical Trials; Collaborations; Data Set; Development; Disease remission; Distress; Educational Status; Epidemic; Epidemiology; Faculty; Fellowship; Female; Fostering; Funding; Goals; Grant; Health; Incidence; Incontinence; Inflammation; Institution; Interdisciplinary Study; K-Series Research Career Programs; Leadership; Lower urinary tract; Medicine; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Obesity; Pelvis; Physical activity; Positioning Attribute; Prevalence; Prevention; Productivity; Program Development; Quality of life; Reconstructive Surgical Procedures; Recording of previous events; Recruitment Activity; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Role; SECTM1 gene; Scientist; Stress; Teacher Professional Development; Testing; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Urinary Incontinence; Weight; Woman; Work; associated symptom; career; career development; daily functioning; effective therapy; improved outcome; innovation; interest; lower urinary tract symptoms; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient oriented research; programs; public health relevance; regenerative; research study; skills; treatment effect; treatment strategy

 DESCRIPTION (provided by applicant): Urinary incontinence (UI) and lower urinary tract symptoms (LUTS) affect almost half of US women and cause substantial distress, diminished quality of life, and dramatic limitations in daily functioning. Obesity, a US and worldwide epidemic associated with enormous health and quality of life impact, is one of the strongest independent risk factors for UI and weight loss is an effective treatment for UI. However, the mechanisms by which obesity promotes UI and LUTS and why weight loss is an effective or UI in women are poorly understood. This proposal outlines a 5-year K24 Midcareer Investigator Award in Patient-Oriented Research (POR) renewal application for the candidate to expand her mentoring work with early career patient oriented researchers and promote a multidisciplinary, translational research paradigm focused on the association of weight and weight loss with UI and LUTS. In addition to mentoring plans, the proposal outlines specific aims to continue to advance our understanding of the association of UI, LUTS, and obesity in women by examining the effect of weight and weight loss on UI/LUTS in women, the possible roles of inflammation, physical activity, stress, and body habitus in the relationship between obesity and UI/LUTS, and facilitate the translational development of novel approaches to treatment and prevention of these conditions. The goals of this patient-oriented research and mentoring proposal will be achieved by efficiently leveraging existing resources, including ongoing NIH-funded clinical trials, comprehensive datasets, and productive research collaborations. The candidate's long-term goals are to be a leader in UI research, to contribute substantially to our understanding and approaches to the treatment and prevention of UI and LUTS, and to mentor the "next generation" of investigators interested in the epidemiology and treatment of female incontinence. Elucidating the mechanisms of the association between obesity with UI and LUTS in women will facilitate the translational development of novel approaches to treatment and prevention of these conditions. Strengths of the candidate include her formal training in research methods, history of research productivity and NIH funding, and a successful track record of mentoring junior trainees. Strengths of the institution include the resources of the UCSF CTSI and K30 Clinical Research Curriculum Award, several K12 training grants from which to recruit mentees, a unique formal mentor training program, and the availability of resources to foster research of junior POR investigators. The candidate has the enthusiastic support of her department, the UCSF CTSI, and patient-oriented research collaborators to pursue her research goals. The protected time provided by the K24 program is critical for the candidate to continue mentoring the "next generation" of investigators committed to patient-oriented research in the female lower urinary tract and advancing innovative research on the obesity-UI/LUTS associations.