Obesity and Urinary Incontinence (OUI)

描述（由申请人提供）： 莱斯利湖Subak，MD是加州大学弗朗西斯科分校（UCSF）的产科、妇科和生殖科学、泌尿学和流行病学副教授，拥有作为研究人员、临床医生和导师的良好记录。她是UCSF妇女生殖健康研究职业发展计划的联合项目主任，UCSF/Mount Zion妇女健康临床研究中心奖学金主任，以及UCSF临床与转化科学研究所（CTSI）导师发展计划（MDP）的核心开发团队。她领导了一个富有成效的以患者为导向的研究计划，并成功地帮助启动了几个初级研究人员的职业生涯。 拟议研究的总体目标是阐明女性肥胖和尿失禁（Ul）之间的关联机制，并促进治疗和预防新方法的转化发展。我们将研究身体质量指数（BMI）和UI之间的纵向关联，评估脂肪细胞因子在BMI-UI关系中的可能作用，并确定发生UI和现有UI进展或消退的独立风险因素。将分析来自NIH资助研究的问卷调查、实验室和结局数据，包括随机试验、基于人群的前瞻性队列研究和减肥手术队列研究。Subak博士将利用她的研究作为指导临床研究人员的平台，并将促进多学科的转化研究方法。她将继续扩大她正在进行的个别年轻研究人员的指导，是在建立创新的CTSI赞助的MDP的领导者，以培养下一代导师，并建立一个综合的临床和研究奖学金计划泌尿科和泌尿妇科在UCSF。 候选人的优势包括她在研究方法，研究生产力和NIH资助的历史，以及指导初级学员的早期跟踪记录的正式培训。该机构的优势包括CTSI和K30的资源，几个K12培训赠款，从中招募学员，一个独特的正式导师培训计划和资源的可用性，以促进初级研究人员的研究。 博士苏巴克有她的部门，UCSF CTSI和转化研究合作者的热情支持，以追求她的研究目标。该奖项将有助于推进她对BMI-UI协会的创新研究以及减肥对女性UI的影响，并指导致力于以患者为导向的尿失禁研究的“下一代”研究人员。

DESCRIPTION (provided by applicant): Leslee L. Subak, MD is Associate Professor of Obstetrics, Gynecology & Reproductive Sciences, Urology & Epidemiology at the University of California, San Francisco (UCSF) with an established track record as a researcher, clinician and mentor. She is Co-Program Director of the UCSF Women's Reproductive Health Research Career Development Program, Director of the UCSF/Mount Zion Women's Health Clinical Re-search Center Fellowship and on the core development team for the UCSF Clinical & Translational Sciences Institute's (CTSI) Mentor Development Program (MDP). She leads a productive patient-oriented research program with active R01's and has successfully helped launch the careers of several junior investigators. The overarching aims of the proposed research are to elucidate the mechanisms of the association between obesity and urinary incontinence (Ul) in women and facilitate the translational development of novel approaches to treatment and prevention. We will investigate the longitudinal association between body mass index (BMI) and Ul, evaluate the possible role of adipocytokines in the BMI-UI relationship and identify independent risk factors for incident Ul and progression or regression of existing Ul. Questionnaire, laboratory and outcome data from NIH-funded studies, including a randomized trial, a population-based prospective cohort study and a cohort study of bariatric surgery, will be analyzed. Dr. Subak will use her research as a platform for mentoring clinical researchers and will promote a multidisciplinary, translational research approach to Ul. She will continue to expand her ongoing mentorship of individual young investigators, be a leader in building the innovative CTSI-sponsored MDP to train the next generation of mentors and establish an integrated clinical and research fellowship program for Urology and Urogynecology at UCSF. Strengths of the candidate include her formal training in research methods, history of research productivity and NIH funding, and an early track record of mentoring junior trainees. Strengths of the institution include the resources of the CTSI and K30, several K12 training grants from which to recruit mentees, a unique formal mentor training program and the availability of resources to foster research of junior investigators. Dr. Subak has the enthusiastic support of her department, the UCSF CTSI and translational research collaborators to pursue her research goals. This award will be instrumental in advancing her innovative research on the BMI-UI association and the effect of weight loss on Ul in women, and in mentoring the "next generation" of investigators committed to patient-oriented research in urinary incontinence.