Patient Oriented Research and Mentoring in Obesity and Urinary Incontinence

以患者为中心的肥胖和尿失禁研究和指导

• 批准号: 9769000
• 负责人: LESLEE L SUBAK
• 金额: $ 18.6万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769000
• 关键词: Affect; Award; Body Weight Changes; Body Weight decreased; Clinical Research Curriculum Award; Clinical Trials; Collaborations; Data Set; Development; Disease remission; Distress; Educational Status; Epidemic; Epidemiology; Faculty; Fellowship; Female; Fostering; Funding; Goals; Grant; Health; Incidence; Incontinence; Inflammation; Institution; Interdisciplinary Study; K-Series Research Career Programs; Leadership; Lower urinary tract; Medicine; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Obesity; Pelvis; Physical activity; Positioning Attribute; Prevalence; Prevention; Productivity; Program Development; Quality of life; Reconstructive Surgical Procedures; Recording of previous events; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Role; SECTM1 gene; Scientist; Stress; Teacher Professional Development; Testing; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Urinary Incontinence; Weight; Woman; Work; associated symptom; career; career development; daily functioning; effective therapy; improved outcome; innovation; interest; lower urinary tract symptoms; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient oriented research; programs; public health relevance; recruit; regenerative; research study; skills; treatment effect; treatment strategy

 DESCRIPTION (provided by applicant): Urinary incontinence (UI) and lower urinary tract symptoms (LUTS) affect almost half of US women and cause substantial distress, diminished quality of life, and dramatic limitations in daily functioning. Obesity, a US and worldwide epidemic associated with enormous health and quality of life impact, is one of the strongest independent risk factors for UI and weight loss is an effective treatment for UI. However, the mechanisms by which obesity promotes UI and LUTS and why weight loss is an effective or UI in women are poorly understood. This proposal outlines a 5-year K24 Midcareer Investigator Award in Patient-Oriented Research (POR) renewal application for the candidate to expand her mentoring work with early career patient oriented researchers and promote a multidisciplinary, translational research paradigm focused on the association of weight and weight loss with UI and LUTS. In addition to mentoring plans, the proposal outlines specific aims to continue to advance our understanding of the association of UI, LUTS, and obesity in women by examining the effect of weight and weight loss on UI/LUTS in women, the possible roles of inflammation, physical activity, stress, and body habitus in the relationship between obesity and UI/LUTS, and facilitate the translational development of novel approaches to treatment and prevention of these conditions. The goals of this patient-oriented research and mentoring proposal will be achieved by efficiently leveraging existing resources, including ongoing NIH-funded clinical trials, comprehensive datasets, and productive research collaborations. The candidate's long-term goals are to be a leader in UI research, to contribute substantially to our understanding and approaches to the treatment and prevention of UI and LUTS, and to mentor the "next generation" of investigators interested in the epidemiology and treatment of female incontinence. Elucidating the mechanisms of the association between obesity with UI and LUTS in women will facilitate the translational development of novel approaches to treatment and prevention of these conditions. Strengths of the candidate include her formal training in research methods, history of research productivity and NIH funding, and a successful track record of mentoring junior trainees. Strengths of the institution include the resources of the UCSF CTSI and K30 Clinical Research Curriculum Award, several K12 training grants from which to recruit mentees, a unique formal mentor training program, and the availability of resources to foster research of junior POR investigators. The candidate has the enthusiastic support of her department, the UCSF CTSI, and patient-oriented research collaborators to pursue her research goals. The protected time provided by the K24 program is critical for the candidate to continue mentoring the "next generation" of investigators committed to patient-oriented research in the female lower urinary tract and advancing innovative research on the obesity-UI/LUTS associations.

 描述(申请人提供)：尿失禁(UI)和下尿路症状(LUTS)影响着几乎一半的美国女性，并导致严重的痛苦，生活质量下降，以及日常功能的严重限制。肥胖是美国和世界范围内的一种流行病，与巨大的健康和生活质量影响有关，是尿崩症最强烈的独立危险因素之一，减肥是治疗尿崩症的有效方法。然而，肥胖促进尿失禁和下尿路结石的机制，以及为什么减肥对女性来说是有效的或尿失禁的原因还知之甚少。该提案概述了一项为期5年的K24以患者为中心的研究(POR)中期研究人员奖续签申请，以扩大她与职业生涯早期以患者为导向的研究人员的指导工作，并促进专注于减肥与UI和LUTS之间的关联的多学科、转化性研究范式。除了指导计划外，该提案还概述了具体目标，旨在通过研究体重减轻对女性尿路/下尿路综合征的影响，炎症、体力活动、压力和身体习惯在肥胖和尿路/下尿路之间的关系中的可能作用，继续推进我们对女性尿路、下尿路和肥胖之间的关联的理解，并促进治疗和预防这些疾病的新方法的翻译开发。这项以患者为中心的研究和指导方案的目标将通过有效利用现有资源来实现，包括正在进行的NIH资助的临床试验、全面的数据集和富有成效的研究合作。候选人的长期目标是成为尿失禁研究的领导者，为我们对尿失禁和下尿路感染的治疗和预防的理解和方法做出重大贡献，并指导对女性尿失禁的流行病学和治疗感兴趣的“下一代”研究人员。阐明肥胖与女性尿失禁和下尿路感染之间的联系机制，将促进治疗和预防这些疾病的新方法的转化发展。应聘者的优势包括她在研究方法、研究生产力和NIH资金方面的正式培训，以及指导初级学员的成功记录。该机构的优势包括加州大学旧金山分校的CTSI和K30临床研究课程奖的资源，几个可供招募学员的K12培训补助金，一个独特的正式导师培训计划，以及可用于促进初级POR研究人员研究的资源。这位候选人得到了她所在部门、加州大学旧金山分校CTSI和以患者为导向的研究合作者的热情支持，以追求她的研究目标。K24计划提供的保护时间对于候选人继续指导致力于女性下尿路以患者为导向的研究并推进肥胖-UI/LUTS关联的创新研究的“下一代”研究人员至关重要。

项目成果

Strategies for evaluating self-efficacy and observed success in the practice of yoga postures for therapeutic indications: methods from a yoga intervention for urinary incontinence among middle-aged and older women.

评估自我效能的策略和观察瑜伽姿势练习治疗适应症的成功：中老年女性尿失禁的瑜伽干预方法。

• DOI: 10.1186/s12906-020-02934-3
• 发表时间: 2020
• 期刊: BMC complementary medicine and therapies
• 影响因子: 3.9
• 作者: Nicosia,FrancescaM;Lisha,NadraE;Chesney,MargaretA;Subak,LesleeL;Plaut,TraciM;Huang,Alison
• 通讯作者: Huang,Alison

Obesity and urinary incontinence: epidemiology and clinical research update.

• DOI: 10.1016/j.juro.2009.08.071
• 发表时间: 2009-12
• 期刊: The Journal of urology
• 作者: Subak LL;Richter HE;Hunskaar S
• 通讯作者: Hunskaar S

A group-based yoga program for urinary incontinence in ambulatory women: feasibility, tolerability, and change in incontinence frequency over 3 months in a single-center randomized trial.

针对流动女性尿失禁的团体瑜伽计划：单中心随机试验的可行性、耐受性以及 3 个月内尿失禁频率的变化。

• DOI: 10.1016/j.ajog.2018.10.031
• 发表时间: 2019
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Huang,AlisonJ;Chesney,Margaret;Lisha,Nadra;Vittinghoff,Eric;Schembri,Michael;Pawlowsky,Sarah;Hsu,Amy;Subak,Leslee
• 通讯作者: Subak,Leslee

Diabetes, obesity and erectile dysfunction: field overview and research priorities.

• DOI: 10.1016/j.juro.2009.07.089
• 发表时间: 2009-12
• 期刊: The Journal of urology
• 作者: Chitaley K;Kupelian V;Subak L;Wessells H
• 通讯作者: Wessells H

A group-based yoga therapy intervention for urinary incontinence in women: a pilot randomized trial.

基于小组的瑜伽治疗妇女尿失禁的干预：一项试验随机试验。

• DOI: 10.1097/spv.0000000000000072
• 发表时间: 2014-05
• 期刊: Female pelvic medicine & reconstructive surgery
• 影响因子: 1.6
• 作者: Huang AJ;Jenny HE;Chesney MA;Schembri M;Subak LL
• 通讯作者: Subak LL