CORE--Analytic

核心——分析

• 批准号: 7898677
• 负责人: ALAN CHAIT
• 金额: $ 21.69万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7898677
• 关键词: Allied Health Profession; Animals; Area; Arts; Atherosclerosis; Basic Science; Biological Assay; Body Composition; Body Weight; Chronic Disease; Clinical; Clinical Investigator; Clinical Nutrition; Clinical Research; Collaborations; Core Facility; Diabetes Mellitus; Diet; Discipline; Disease; Education; Effectiveness; Energy Metabolism; Environment Design; Fostering; Genetic; Goals; Health; Human; Interdisciplinary Study; Knowledge; Lipids; Measures; Medical Students; Mission; Nature; Nutrient; Nutritional; Nutritional Study; Obesity; Patients; Physicians; Physiology; Productivity; Regulation; Research; Research Activity; Research Personnel; Resources; Rodent; Schools; Scientist; Series; Services; Students; Universities; Visit; Washington; base; cost; effectiveness research; gene interaction; human subject; improved; interest; method development; mouse model; multidisciplinary; nutrition; nutrition education; programs; response

The major goal of the Clinical Nutrition Research Unit (CNRU) at the University of Washington is to promote and enhance interdisciplinary nutrition research by bringing together basic science and clinical investigators on a cooperative basis. Because of the multidisciplinary nature of nutrition, close interaction across disciplines and optimal use of resources is necessary to better understand the relationships among diet, health and disease states. By providing a number of Core facilities, the CNRU integrates and coordinates research activities in the field of nutrition and aims to foster new interdisciplinary research collaboration, stimulate new research activities, improve nutrition education at multiple levels and facilitate the nutritional management of patients. The four Cores are: 1) an Animal Studies Core, the Physiology Component of which measures body composition and energy expenditure in rodents, and a Genetic Component, which provides geneticallydefined mouse models for use in studies of nutrient-gene interactions; 2) an Analytic Core to provide Affiliate Investigators with cost-efficient state-of-the-art nutritional assays in both human subjects and experimental animals, and to help with new methods development; 3) a Human Studies Core to provide facilities and assistance for investigators with their clinical research, and 4) an Administrative and Enrichment Core that is responsible for the day-to-day administration of the CNRU. This Core also arranges a series of seminars, retreats, and Visiting Professorships, and administers the Pilot and Feasibility and New Investigator Programs. These programs are aimed at stimulating nutrition research by junior investigators and by more established investigators new to the field of nutrition in response to evolving research interests at the University of Washington. This Core also contains a biostatistical component that supports both basic and clinical research. Thus, the CNRU provides facilities and support for the large and varied nutrition research base of the University, which consists of 78 Affiliate Investigators. The major research foci of the University of Washington's CNRU are lipids and atherosclerosis, diabetes and body weight regulation, and obesity, i.e chronic diseases of major importance to the health of the nation. The presence of the CNRU at the University of Washington stimulates not only research, but also educational and clinical activities in the area of nutrition.

华盛顿大学临床营养研究部（CNRU）的主要目标是 通过将基础科学和临床结合在一起来促进和增强跨学科的营养研究 调查人员合作。由于营养的多学科性质，请紧密互动 跨学科和资源的最佳利用对于更好地了解 饮食，健康和疾病状态。通过提供许多核心设施，CNRU整合并 协调营养领域的研究活动，旨在促进新的跨学科研究 协作，刺激新的研究活动，改善多个层次的营养教育并促进 患者的营养管理。 这四个核心是：1）动物研究核心，其生理组成部分测量了身体 啮齿动物的组成和能量消耗，以及提供遗传定义的遗传成分 小鼠模型用于营养基因相互作用的研究； 2）提供的分析核心 在人类受试者和 实验动物，并帮助新方法开发； 3）人类研究核心提供 通过临床研究为调查人员提供的设施和协助，以及4）行政和 负责CNRU日常管理的富集核心。也是这个核心 安排一系列研讨会，务虚会和访问教授职位，并管理飞行员和 可行性和新调查员计划。这些计划旨在通过 初级调查人员以及更知名的营养领域的研究人员，以应对 华盛顿大学不断发展的研究兴趣。该核心还包含生物统计学 支持基础研究和临床研究的组成部分。 因此，CNRU为大型和多样化的营养研究基础提供了设施和支持 大学，由78位会员调查员组成。大学的主要研究重点 华盛顿的CNRU是脂质和动脉粥样硬化，糖尿病和体重调节，肥胖，即 对国家健康至关重要的慢性疾病。 CNRU在 华盛顿大学不仅刺激了研究，还刺激了教育和临床活动 营养区域。