IMPORTANCE OF ANTIBODY ISOTYPE IN VAGINAL HIV TRANSMISSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 现在很清楚，肠和其他粘膜组织在HIV感染的传播和早期发病机制中具有重要意义。 去年，我们证明了HIV特异性伊加和IgG在静脉注射后分别优先从肠道（直肠）和阴道分泌。 我们现在正在确定是否全身或阴道内注射伊加或IgG可能更好地保护免受阴道SHIV攻击。例如，如果我们发现伊加同种型的抗HIV抗体比IgG同种型更具保护性，这可能与HIV疫苗设计高度相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is now clear that intestine and other mucosal tissues are of major importance in both the transmission as well as the early pathogenesis of HIV infection. Last year we demonstrated that HIV-specific IgA and IgG are preferentially secreted from the intestine (rectum) and vagina, respectively following intravenous administration. We are now determining whether systemic or intravaginal administration of IgA or IgG may be better at protection against a vaginal SHIV challenge. For example, if we find that anti-HIV antibodies when in an IgA isotype are more protective than IgG isotypes, this could be highly relevant for HIV vaccine design.