IN VIVO SAFETY AND EFFICACY OF CAP FILM AND MICROBICIDE COMBINATIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景：选择一种新的CAP阴道栓剂配方用于恒河猴的分散和全包衣研究。 方法：将阴道托插入4只动物的阴道穹窿，后腿抬高。后端保持升高半小时，并进行观察以检查子宫托的分散和均匀涂层。 结果/讨论：即使在进入阴道穹窿1小时后，阴道栓也未能溶解。 目前;我们正在研究一种新的CAP制剂，它可以在合理的时间内溶解，覆盖阴道粘膜，并提供对致病性SHIV的保护。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: A new CAP vaginal pessary formulatiion was selected for dispersion and full coating study in rhesus macaques. Methods: The pessary was inserted into the vaginal vault of 4 animals with their hind legs raised. The hind end remained elevated for half hour and observations were made to examine the dispersion and even coating of the pessary. Results/Discussion: The pessary failed to dissolve even after an hour into the vaginal vault. Currently; we are working on a new formulation of CAP that can dissolve in a reasonable time, coat the vaginal mucosa and afford protection against pathogenic SHIV.