TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
批准号:
8358042
负责人:
CECILIA C CHENG-MAYER
金额:
$5.78万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
AnimalsAppearanceCXCR4 geneDisadvantagedDiseaseFundingGrantHIV-1MacacaModelingMolecularNational Center for Research ResourcesPathogenesisPathway interactionsPopulationPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesSourceStagingUnited States National Institutes of HealthViruscostfitnessin vivosimian human immunodeficiency virustransmission process
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Fitness disadvantage of the transitional intermediates compared to the initial R5 viruses has been suggested to constitute one of the blockades to coreceptor switching, explaining the late appearance of X4 viruses. Using a simian model for human immunodeficiency virus type 1 (HIV-1) coreceptor switching, we demonstrate in this study that similar molecular evolutionary pathways to coreceptor switch occur in more than one R5 simian/human immunodeficiency virus (SHIV)(SF162P3N)-infected macaque. In infected animals where multiple pathways for expansion or switch to CXCR4 coexist, fitness of the transitional intermediates in coreceptor usage efficiency influences their outgrowth and representation in the infecting virus population. Dualtropic and X4 viruses appear at different disease stages, but they have lower entry efficiency than the coexisting R5 strains, which may explain why they do not outcompete the R5 viruses. Similar observations were made in two infected macaques with coreceptor switch, providing in vivo evidence that fitness disadvantage is an obstacle to X4 emergence and expansion.
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会议论文
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批准号:8845512
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项目类别:
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资助金额:$86.54万
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财政年份:2014
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负责人:CECILIA C CHENG-MAYER
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依托单位:
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财政年份:2012
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依托单位:
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批准号:8330127
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项目类别:
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资助金额:$49.73万
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财政年份:2012
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负责人:CECILIA C CHENG-MAYER
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依托单位:
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批准号:8358053
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:CECILIA C CHENG-MAYER
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依托单位:
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批准号:8358088
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:CECILIA C CHENG-MAYER
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依托单位:
R5 SHIV/MACAQUE MODEL FOR THE EVALUATION OF T AND B CELL-BASED HIV-1 VACCINE
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批准号:8358132
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:CECILIA C CHENG-MAYER
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依托单位:
R5 SHIV/MACAQUE MODEL FOR THE EVALUATION OF T AND B CELL-BASED HIV-1 VACCINE
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批准号:8173045
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:CECILIA C CHENG-MAYER
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依托单位:
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批准号:8172991
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:CECILIA C CHENG-MAYER
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依托单位:
PHENOTYPIC AND GENOTYPIC DETERMINANTS OF SHIV PATHOGENESIS
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批准号:8172945
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:CECILIA C CHENG-MAYER
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依托单位:
TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
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批准号:8172933
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:CECILIA C CHENG-MAYER
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依托单位:
REFINEMENT OF THE SHIV/MACAQUE MODEL FOR ASSESSMENT OF CANDIDATE MICROBICIDES
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批准号:8172990
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:CECILIA C CHENG-MAYER
-
依托单位:
COMBINATION VACCINE/MICROBICIDE EFFICACY ASSESSMENT IN THE SHIV/MACAQUE MODEL
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批准号:8172988
-
项目类别:
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资助金额:$6.18万
-
财政年份:2010
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负责人:CECILIA C CHENG-MAYER
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依托单位:
PHENOTYPIC AND GENOTYPIC DETERMINANTS OF SHIV PATHOGENESIS
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批准号:7958606
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项目类别:
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资助金额:$6.27万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
COMBINATION VACCINE/MICROBICIDE EFFICACY ASSESSMENT IN THE SHIV/MACAQUE MODEL
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批准号:7958668
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项目类别:
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资助金额:$6.27万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
IN VIVO SAFETY AND EFFICACY OF CAP FILM AND MICROBICIDE COMBINATIONS
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批准号:7958671
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项目类别:
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资助金额:$6.27万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
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批准号:8720239
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项目类别:
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资助金额:$74.88万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
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批准号:7932175
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项目类别:
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资助金额:$86.92万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
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批准号:7760762
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项目类别:
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资助金额:$89.75万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
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批准号:7958670
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项目类别:
-
资助金额:$6.27万
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财政年份:2009
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负责人:CECILIA C CHENG-MAYER
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依托单位:
海外基金