Neuroimaging Core

SPOTRIAS Neuroimaging Core的使命是开发、安装和维护该技术 基础设施，并提供服务，以支持三个SPOTRIAS的神经成像组件 研究项目。这些核心功能将包括以下组件： 使图像传输从图片存档和通信系统（PACS）在参与 SPOTRIAS医院（马萨诸塞州总医院（MGH）和布里格姆妇女医院（BWH）， Boston，MA）至位于MGH的神经影像学中心，对图像进行匿名化/设盲，提供 工作站和支持放射学图像审查，执行病变大小的定量测量 各种影像、放射学数据采集和管理，以及将影像结果转换为 数据库/统计核心，用于与临床初始和结局数据相关的统计分析。所有三 SPOTRIAS研究项目包括中风神经影像学评估和分析，患者可能 参与这三个研究项目中的一个以上。神经影像学核心将统一 这些功能在SPOTRIAS研究项目中。因此，该核心将提供标准化， 在非造影CT扫描（CTA）上对病变大小进行一致且有效的放射学测量 源图像和CBV、CBF和MTT图。生成的数据将在重叠的 项目核心将提供成像数据，作为独立的，可验证的测量， 常压氧疗法治疗项目中患者的病变大小发生变化，此外， 作为一个集中的计算机化资源，使有效的神经成像存储，审查， 测量.神经影像学核心的主要目标是开发一个集中的设施， 扫描的放射学检查，以及对卒中相关的 来自连续CT图像（包括非增强CT、CTA源和最大强度）的病变 投影图像、CT灌注等）。分析结果将导入SPOTRIAS数据库， 它还将包含来自所有三个项目的临床信息。核心小组将管理 用于创建提供定量和放射成像的集中服务的基础设施和软件 所有三个项目的指标，图像来自参与SPOTRIAS的医院（MGH和 BWH）。

The mission of the SPOTRIAS Neuroimaging Core is to develop, install, and maintain the technology infrastructure and provide services to support the neuroimaging components of the three SPOTRIAS research projects. These Core functions will include the following components: image communication to enable image transfer from the picture archive and communication systems (PACS) at the participating SPOTRIAS hospitals (Massachusetts General Hospital (MGH) and Brigham and Women's Hospitals (BWH), Boston, MA) to the Neuroimaging Core located at MGH, anonymization/blinding of the images, providing workstations and support for radiological image review, performing quantitative measurements of lesion size on the various images, radiological data capture and management, and translation of imaging results to the database/statistics core for statistical analysis in relation to the clinical initial and outcomes data. All three SPOTRIAS research projects include stroke neuroimaging evaluation and analysis, with patients who may participate in more than one of these three research projects. The Neuroimaging Core will serve to unify these functions across the SPOTRIAS research projects. Thus, this Core will provide standardized, consistent, and efficient radiological measurements of lesion size on the non-contrast CT scans, the CTA source images and the CBV, CBF, and MTT maps. Resulting data will be shared among overlapping projects. The Core will provide the imaging data that will serve as independent, verifiable measurement of change in lesion size for patients in the normobaric oxygen therapy treatment project, and will additionally serve as a centralized computerized resource to enable efficient neuroimaging storage, review, and measurements. The primary goal of the Neuroimaging Core is to develop a centralized facility for radiological review of scans, and also for making reliable, quantitative volumetric measurements of strokerelated lesions from serial CT images (including non-contrast CT, CTA source and maximum intensity projection images, CT perfusion, etc.). Results of analyses will be imported into the SPOTRIAS database, which will also contain clinical information from all three projects. The Core will manage implementation of infrastructure and software for creating a centralized service to provide quantitative and radiological imaging metrics for all three projects, with images originating from both participating SPOTRIAS hospitals (MGH and BWH).