Specialized Program of Translational Research in Acute Stroke at the Partners Hea

合作伙伴医院急性中风转化研究专门项目

• 批准号: 7880554
• 负责人: Michael Lev
• 金额: $ 25.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7880554
• 关键词: Acute; Area; Benign; Blood Volume; Brain; Brain region; Cerebrovascular Circulation; Cessation of life; Characteristics; Clinical; Core-Binding Factor; Data; Data Set; Enrollment; Goals; Handedness; Hour; Image; Infarction; Intervention; Investigation; Linear Models; Location; Methods; Modeling; Neurologic; Noise; Outcome; Patients; Perfusion; Principal Investigator; Process; Receiver Operator Characteristics; Recovery; Relative (related person); Reperfusion Therapy; Risk; Scanning; Sensitivity and Specificity; Slice; Source; Specificity; Testing; Time; Tissue Preservation; Tissue Survival; Tissues; Translational Research; Weight; Work; acute stroke; base; cohort; comparative; cone-beam computed tomography; functional outcomes; ischemic lesion; model development; novel; predictive modeling; programs; time use; tool

The long-range goal of this work is to develop and validate a novel, clinically useful, location-weighted CT perfusion (CTP) based tool to predict the maximal clinical recovery attributable to salvage of ischemic tissue with reperfusion. The first step is to ascertain how best to predict tissue fate depending on whether or not there is early reperfusion. Although this in itself would be a major advance, the goal of acute stroke treatment is to minimize neurological deficit and maximize functional outcome. Predicting only potential tissue salvage is inadequate to assess the risk versus benefit of intervention, except for extreme cases, i.e., large volume of tissue at risk, or no salvageable tissue. A method that predicts expected clinical improvement based on extent and location of tissue salvage is the ultimate goal of acute stroke imaging. Owing to the superior quantitative capability of CT, as opposed to MR, perfusion imaging, the application of specific CT cerebral blood flow (CT-CBF) and blood volume (CT-CBV) thresholds to predict tissue survival or infarction appears promising. Because smaller studies have suggested that the calculated volume salvaged by reperfusion is correlated with improvement in NIHSS, it is essential that these thresholds be validated in larger patient cohorts for which reperfusion status is known. In Aims 1 and 2, we will therefore establish CTP thresholds for "core" (tissue likely to die despite reperfusion) and "benign oligemia" (tissue likely to survive despite persistent hypoperfusion). Ischemic tissue with CTP values between these extremes reflects "unstable penumbra" (tissue with variable outcome, depending on the degree, extent, and timing of reperfusion). In Aim 2.iii, we will confirm that CT angiographic source images (CTA-SI), which cover the entire brain, require no post processing, and are available immediately at scan completion, can also be used to sensitively determine infarct "core". In Aim 3, we will begin to develop a clinical prediction model to estimate "maximal expected clinical improvement in NIHSS scoring associated with reperfusion".

这项工作的长期目标是开发和验证一种新的、临床上有用的位置加权CT 基于灌注(CTP)的工具预测可归因于挽救缺血组织的最大临床恢复 再灌流。第一步是确定如何最好地预测组织的命运，这取决于 存在早期再灌流。尽管这本身就是一个重大进步，但急性中风治疗的目标是 最大限度地减少神经缺陷，最大限度地提高功能。只预测潜在的组织挽救 不足以评估干预的风险与收益，但极端情况除外，即 有危险的组织，或者没有可挽救的组织。一种预测预期临床改善的方法，基于 组织挽救的范围和位置是急性卒中成像的最终目标。 由于与MR相比，CT具有更优越的定量能力，因此 特异性CT脑血流量(CT-CBF)和血容量(CT-CBV)阈值预测组织存活或 脑梗塞看起来很有希望。因为规模较小的研究表明，计算出来的打捞出来的体积 通过再灌注与NIHSS的改善相关，这些阈值在 已知再灌流状态的较大患者队列。因此，在目标1和目标2中，我们将建立CTP “核心”(再灌流后可能死亡的组织)和“良性少血症”(可能存活的组织)的阈值 尽管持续低灌注率)。CTP值介于这两个极端之间的缺血组织反映 “不稳定半影区”(结果不稳定的组织，取决于程度、程度和时机 再灌流)。在目标2.iii中，我们将确认CT血管造影源图像(CTA-SI)覆盖了 整个大脑，不需要后处理，扫描完成后立即可用，也可以使用 以灵敏地确定梗塞的“核心”。在目标3中，我们将开始开发一个临床预测模型来 估计“与再灌注相关的NIHSS评分的最大预期临床改善”。