Molecular and Epidemiologic Characterization of Salivary Gland Carcinomas

唾液腺癌的分子和流行病学特征

• 批准号: 7935295
• 负责人: ADEL K. EL-NAGGAR
• 金额: $ 116.77万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-20 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935295
• 关键词: Access to Information; Adenocarcinoma; Behavior; Biological Markers; Biological Markers; Categories; Cell Line; Clinical; Common Neoplasm; Databases; Disease Marker; Epidemiology; Epigenetic Process; Evaluation; Factor Analysis; Gene Silencing; Genes; Genetic; Genomics; Goals; Grant; Head and neck structure; Human; Infrastructure Activities; Malignant Neoplasms; Malignant neoplasm of salivary gland; Mentors; Methylation; Microarray Analysis; Molecular; Online Systems; Operative Surgical Procedures; Patients; Physicians; Pilot Projects; Radiation therapy; Risk Factors; Role; Salivary; Salivary Gland Carcinoma; Salivary Gland Neoplasms; Salivary Glands; Sampling; Screening procedure; Standardization; Therapeutic; Tissues; Training; Tumor Suppressor Genes; United States; carcinogenesis; career; career development; chemotherapy; mouse model; outcome forecast; patient advocacy group; programs; promoter; public health relevance; therapeutic target; tumor

DESCRIPTION (provided by applicant): Salivary gland malignancies represent only 1-2% of all head and neck malignancies in the United States. Their behavior can be quite variable, and treatment usually involves surgery and radiation therapy. Because not much is known about the molecular mechanisms of these unusual tumors, chemotherapy and other targeted therapies have not been shown to be effective. As part of this collaborative proposal, our aim is to evaluate the role of promoter methylation as a means of tumor suppressor gene silencing using new microarray technology. We intend to use the Illumina Human Methylation27 array which is able to sample the methylation status of over 14,000 genes. We can then validate the identified targets and go on to perform further mechanistic studies of their biologic relevance in these malignancies. Performing this comprehensive analysis will allow us to determine the effect of epigenetic silencing on the carcinogenesis of salivary gland cancers. PUBLIC HEALTH RELEVANCE: The goal of this grant is to help identify the significance of methyaltion in salivary gland cancers with the hopes of providing either therapeutic targets or markers for disease that can be used for prognosis or screening.

描述（由申请方提供）：涎腺恶性肿瘤仅占美国所有头颈部恶性肿瘤的1-2%。他们的行为可能是相当多变的，治疗通常包括手术和放射治疗。由于对这些不寻常肿瘤的分子机制知之甚少，化疗和其他靶向治疗尚未显示出有效性。作为这项合作提案的一部分，我们的目标是使用新的微阵列技术评估启动子甲基化作为肿瘤抑制基因沉默手段的作用。我们打算使用Illumina人类甲基化27阵列，该阵列能够对超过14，000个基因的甲基化状态进行采样。然后，我们可以验证所确定的靶点，并继续对其在这些恶性肿瘤中的生物学相关性进行进一步的机制研究。进行这种全面的分析将使我们能够确定表观遗传沉默对唾液腺癌发生的影响。公共卫生关系：这项资助的目的是帮助确定甲基化在唾液腺癌中的意义，希望为可用于预后或筛查的疾病提供治疗靶点或标志物。