Molecular and Epidemiologic Characterization of Salivary Gland Carcinomas

唾液腺癌的分子和流行病学特征

• 批准号: 8081912
• 负责人: ADEL K. EL-NAGGAR
• 金额: $ 16.54万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-20 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8081912
• 关键词: Address; Adenocarcinoma; Animal Welfare; Applications Grants; Area; Award; Biological Markers; Biological Markers; Budgets; Businesses; Cell Line; Certification; Cities; Clinical Research; Clinical Trials; Code; Communities; Contracts; Data; Data Analyses; Direct Costs; Disadvantaged; Doctor of Medicine; Doctor of Philosophy; Electronic Mail; Epidemiology; Face; Fostering; Genetic Transcription; Grant; Informatics; Ink; Knowledge; Laboratories; Last Name; Leadership; Length; Letters; Medicine; Molecular; Molecular Epidemiology; Names; Pathology; Patients; Phase; Pilot Projects; Positioning Attribute; Primary Neoplasm; Principal Investigator; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Salivary; Salivary Gland Carcinoma; Salivary Gland Neoplasms; Services; Specimen; Street Address; Techniques; Telephone; Therapeutic; Tissue Array Analysis; Tumor Cell Line; Tumor-Derived; United States Public Health Service; University of Texas M D Anderson Cancer Center; Validation; Woman; career development; cost; epigenomics; professor; programs; response; tumor; validation studies

DESCRIPTION (provided by applicant): Salivary gland malignancies represent only 1-2% of all head and neck malignancies in the United States. Their behavior can be quite variable, and treatment usually involves surgery and radiation therapy. Because not much is known about the molecular mechanisms of these unusual tumors, chemotherapy and other targeted therapies have not been shown to be effective. As part of this collaborative proposal, our aim is to evaluate the role of promoter methylation as a means of tumor suppressor gene silencing using new microarray technology. We intend to use the Illumina Human Methylation27 array which is able to sample the methylation status of over 14,000 genes. We can then validate the identified targets and go on to perform further mechanistic studies of their biologic relevance in these malignancies. Performing this comprehensive analysis will allow us to determine the effect of epigenetic silencing on the carcinogenesis of salivary gland cancers. PUBLIC HEALTH RELEVANCE: The goal of this grant is to help identify the significance of methyaltion in salivary gland cancers with the hopes of providing either therapeutic targets or markers for disease that can be used for prognosis or screening.

描述（由申请人提供）：唾液腺恶性肿瘤仅占美国所有头部和颈部恶性肿瘤的1-2％。它们的行为可能是相当可变的，治疗通常涉及手术和放射治疗。由于这些异常肿瘤的分子机制知之甚少，因此尚未证明化学疗法和其他靶向疗法有效。作为该协作提案的一部分，我们的目的是评估启动子甲基化作为使用新微阵列技术的肿瘤抑制基因沉默的一种手段。我们打算使用Illumina人甲基化27阵列，该阵列能够采样14,000多个基因的甲基化状态。然后，我们可以验证确定的目标，并继续对其在这些恶性肿瘤中的生物学相关性进行进一步的机械研究。进行这种全面的分析将使我们能够确定表观遗传沉默对唾液腺癌的致癌作用的影响。公共卫生相关性：这笔赠款的目的是帮助确定甲基甲虫在唾液腺癌中的重要性，以期提供可用于预后或筛查的疾病的治疗靶标或标志物。