Tumor Model and Biospecimen Repository Core

肿瘤模型和生物样本库核心

• 批准号: 10707167
• 负责人: ADEL K. EL-NAGGAR
• 金额: $ 6.72万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707167
• 关键词: Animal Model; Biological Markers; Biological Specimen Banks; Blood; Cancer cell line; Cell Line; Cell Maintenance; Clinical; Collaborations; Collection; Cytology; Database Management Systems; Databases; Development; Diagnosis; Drug or chemical Tissue Distribution; Ensure; Evaluation; Fine needle aspiration biopsy; Fostering; Genomics; Guidelines; Harvest; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Health Insurance Portability and Accountability Act; Human Resources; Immunohistochemistry; Individual; Laboratories; Lead; Leadership; Link; Malignant - descriptor; Medicine; Modeling; Mus; Nucleic Acids; Pathologic; Pathology; Patients; Preparation; Process; Research; Research Personnel; Resistance; Resources; Sampling; Secure; Services; Specimen; Techniques; Tissue Banks; Tissue Microarray; Tissue Sample; Tissues; United States National Institutes of Health; University of Texas M D Anderson Cancer Center; Western Blotting; college; cytokine; immunosuppressed; innovation; patient derived xenograft model; peripheral blood; programs; repository; tumor

Tumor Model and Biospecimen Repository Core (Core C) SUMMARY Tumor Model and Biospecimen Repository Core (Core C) led by Dr. Adel K. El-Naggar (Core Leader) and Dr. Jeffrey Myers (Core Co-Leader), will provide H-CARR investigators with a centralized facility that ensures the systematic collection, processing, storage, and distribution of peripheral blood, surrogate and specialized specimens, and samples of head and neck squamous cell carcinoma (HNSCC) from patients diagnosed, treated, and followed at The University of Texas MD Anderson Cancer Center (MD Anderson) at Baylor College of Medicine (BCM). Core C also provides expert preparation and distribution of high-quality samples and ancillary techniques to optimize utilization of patients’ materials by H-CARR investigators. Procurement and distribution of the samples to individual investigators will follow the guidelines established by the H-CARR Center Executive Leadership Committee and in compliance with HIPAA. Core C leadership will provide detailed pathologic evaluation of all tumor samples to investigators through the secure pathology database system linked to the H- CARR, database, and server. Core C will perform specialized services, including tissue microarray (TMA) construction, qualitative and quantitative biomarker analyses both in tissue [e.g., immunohistochemistry (IHC), Western blotting] and non-tissue (e.g., blood-based cytokine profiles) specimens, nucleic acid extractions, and development and maintenance of cell lines. Core C will also provide well-characterized, genomically authenticated head and neck cancer cell lines, well-characterized patient-derived xenograft (PDX) models, and heterotopic and orthotopic animal models in immunosuppressed or syngeneic mice and autochthonous tumor models of HNSCC to investigators. The leadership and personnel of Core C and its centralized organization will ensure the highest quality tissue samples and related analyses to all H-CARR investigators and to collaborating researchers participating in other NIH/NCI-sponsored programs.

肿瘤模型和生物测量存储库核心（核心C）摘要 由Adel K. El-Naggar博士（核心负责人）和博士领导 杰弗里·迈尔斯（Jeffrey Myers）（核心共同领导者）将为H-Carr调查人员提供集中式设施，以确保 外周血，替代和专业的系统收集，加工，存储和分布 诊断，治疗， 紧随其后的是德克萨斯大学医学博士安德森癌症中心（MD Anderson） 医学（BCM）。核心C还提供高质量样本和辅助的专家准备和分布 H-CARR研究人员优化使用患者材料利用的技术。采购和分配 这些样本向个人调查人员遵循H-Carr中心执行官制定的指南 领导委员会并符合HIPAA。 C核C领导将提供详细的病理 通过与H-相关的安全病理数据库系统对所有肿瘤样品的评估 Carr，数据库和服务器。 Core C将执行专业服务，包括组织微阵列（TMA） 结构，定性和定量生物标志物在组织中都进行了分析[例如，免疫组织化学（IHC）， 蛋白质印迹]和非组织（例如，基于血液的细胞因子谱）标本，核酸提取和 细胞系的开发和维护。核心C还将在基因组上提供良好的特征 身份验证的头部和颈部癌细胞系，特征良好的患者衍生Xenographotic（PDX）模型以及 免疫抑制或合成小鼠的异位和原位动物模型以及自肿瘤 HNSCC的模型向调查人员。 Core C及其集中组织的领导和人员将 确保对所有H-CARR研究人员进行最高质量的组织样品和相关分析并进行合作 参加其他NIH/NCI赞助的计划的研究人员。