Salivary Gland Tumor Cell Biorepository

唾液腺肿瘤细胞生物样本库

• 批准号: 8551611
• 负责人: ADEL K. EL-NAGGAR
• 金额: $ 401.64万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-10 至 2016-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8551611
• 关键词: Access to Information; Address; Animal Model; Basic Science; Biology; Cataloging; Catalogs; Cell Line; Chronic Myeloid Leukemia; Clinical Data; Communities; Community Health Centers; Data; Databases; Diagnostic; Educational workshop; Electronics; Extramural Activities; Freezing; Grant; Head and neck structure; Housing; Incidence; Institution; Lead; Link; Lymphocyte; Malignant Neoplasms; Malignant neoplasm of salivary gland; Modality; National Institute of Dental and Craniofacial Research; Neoplasm Metastasis; Neoplasms; Online Systems; Operative Surgical Procedures; Paraffin; Paraffin Tissue; Pathologic; Pathology; Patients; Policies; Primary Neoplasm; Public Health; Recruitment Activity; Recurrent tumor; Research; Research Infrastructure; Research Personnel; Resources; Saliva; Salivary Gland Neoplasms; Salivary Glands; Secure; Serum; Specimen; Structure; Tissues; Translational Research; Treatment outcome; Tumor Biology; Tumor Pathology; Tumor Tissue; University of Texas M D Anderson Cancer Center; Unresectable; Work; biobank; computerized; improved; neoplastic cell; tool; tumor

Salivary gland tumors are rare neoplasms with approximately 3,300 new cases per year in the US. While surgery is the main modality of treatment for these tumors, advanced unresectable primary, recurrent and metastatic tumors are generally fatal. It is important to note that the overall incidence for salivary gland malignancies mimics those of chronic myelocytic leukemias (CML), yet federal and private research enterprises for CML far exceed those for the salivary gland tumors. As a result, there have been relatively few investigators working in the field and a critical mass of research tools for investigators to engage in this type of research has not been established. In October 2006, NCI and NIDCR convened the first workshop on the ¿Biology and Treatment of Malignant Salivary Gland Tumors.¿ It was concluded that this field is suffering from lack of progress in all aspects, from basic biology to therapy and patient management. More importantly, the workshop revealed that there is a paucity of research tools such as tissue specimens, cell lines, and animal models that are instrumental in promoting the basic and translational research in the field. Furthermore, a centralized effort to catalogue and collect these resources that can be made available to the extramural community is lacking. In an effort to advance basic and translational research in this field and ultimately improve public health, NIDCR led the effort to support the establishment of a centralized biorepository at an academic institution with known expertise in head and neck and salivary gland tumor biology and pathology NIDCR identified Dr. Adel El-Naggar at MDACC, a nationally and internationally recognized expert in salivary gland tumor biology and pathology, to lead the centralized biorepository. Dr. El-Naggar coordinated the effort to establish a centralized biorepository at MDACC through a consortium of satellite centers that agreed to contribute biospecimens to the biorepository. He identified a core number of experts in salivary gland pathology and biology who could help identify and catalogue biospecimens linked to diagnostic, pathologic, treatment, and outcome data. Through this consortium, the biorepository stores and catalogues fresh frozen salivary gland tumor tissues and paraffin blocks (with matched serum, saliva, lymphocytes, if applicable), as well as associated clinical data. It is anticipated that access to information on biospecimens and associated clinical data will be facilitated through a web-based electronic interface that is searchable online.

唾液腺肿瘤是一种罕见的肿瘤，美国每年约有 3,300 例新发病例。虽然手术是这些肿瘤的主要治疗方式，但晚期不可切除的原发性、复发性和转移性肿瘤通常是致命的。值得注意的是，唾液腺恶性肿瘤的总体发病率与慢性粒细胞白血病 (CML) 相似，但针对 CML 的联邦和私人研究企业远远超过唾液腺肿瘤。因此，该领域的研究人员相对较少，而且尚未建立足够的研究工具供研究人员从事此类研究。 2006年10月，NCI和NIDCR召开了第一届“恶性唾液腺肿瘤的生物学和治疗”研讨会。得出的结论是，该领域从基础生物学到治疗和患者管理等各个方面都缺乏进展。更重要的是，研讨会揭示了组织标本、细胞系、动物模型等有助于促进该领域基础研究和转化研究的研究工具的匮乏。此外，缺乏对这些可供校外社区使用的资源进行集中编目和收集的工作。 为了推进该领域的基础和转化研究并最终改善公众健康，NIDCR 牵头支持在头颈和唾液腺肿瘤生物学和病理学领域拥有知名专业知识的学术机构建立一个集中式生物样本库。NIDCR 指定 MDACC 的 Adel El-Naggar 博士（国内和国际公认的唾液腺肿瘤生物学和病理学专家）来领导集中化生物样本库的建立。 生物储存库。 El-Naggar 博士通过同意向生物样本库提供生物样本的卫星中心联盟协调了在 MDACC 建立中央生物样本库的工作。他确定了唾液腺病理学和生物学领域的核心专家，他们可以帮助识别和编目与诊断、病理、治疗和结果数据相关的生物样本。通过该联盟，生物样本库存储并编目新鲜冷冻唾液腺肿瘤组织和石蜡块（以及匹配的血清、唾液、淋巴细胞，如果适用）以及相关的临床数据。预计通过可在线搜索的基于网络的电子界面将有助于获取生物样本信息和相关临床数据。