Salivary Gland Tumor Cell Biorepository

唾液腺肿瘤细胞生物样本库

• 批准号: 8551611
• 负责人: ADEL K. EL-NAGGAR
• 金额: $ 401.64万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-10 至 2016-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8551611
• 关键词: Access to Information; Address; Animal Model; Basic Science; Biology; Cataloging; Catalogs; Cell Line; Chronic Myeloid Leukemia; Clinical Data; Communities; Community Health Centers; Data; Databases; Diagnostic; Educational workshop; Electronics; Extramural Activities; Freezing; Grant; Head and neck structure; Housing; Incidence; Institution; Lead; Link; Lymphocyte; Malignant Neoplasms; Malignant neoplasm of salivary gland; Modality; National Institute of Dental and Craniofacial Research; Neoplasm Metastasis; Neoplasms; Online Systems; Operative Surgical Procedures; Paraffin; Paraffin Tissue; Pathologic; Pathology; Patients; Policies; Primary Neoplasm; Public Health; Recruitment Activity; Recurrent tumor; Research; Research Infrastructure; Research Personnel; Resources; Saliva; Salivary Gland Neoplasms; Salivary Glands; Secure; Serum; Specimen; Structure; Tissues; Translational Research; Treatment outcome; Tumor Biology; Tumor Pathology; Tumor Tissue; University of Texas M D Anderson Cancer Center; Unresectable; Work; biobank; computerized; improved; neoplastic cell; tool; tumor

Salivary gland tumors are rare neoplasms with approximately 3,300 new cases per year in the US. While surgery is the main modality of treatment for these tumors, advanced unresectable primary, recurrent and metastatic tumors are generally fatal. It is important to note that the overall incidence for salivary gland malignancies mimics those of chronic myelocytic leukemias (CML), yet federal and private research enterprises for CML far exceed those for the salivary gland tumors. As a result, there have been relatively few investigators working in the field and a critical mass of research tools for investigators to engage in this type of research has not been established. In October 2006, NCI and NIDCR convened the first workshop on the ¿Biology and Treatment of Malignant Salivary Gland Tumors.¿ It was concluded that this field is suffering from lack of progress in all aspects, from basic biology to therapy and patient management. More importantly, the workshop revealed that there is a paucity of research tools such as tissue specimens, cell lines, and animal models that are instrumental in promoting the basic and translational research in the field. Furthermore, a centralized effort to catalogue and collect these resources that can be made available to the extramural community is lacking. In an effort to advance basic and translational research in this field and ultimately improve public health, NIDCR led the effort to support the establishment of a centralized biorepository at an academic institution with known expertise in head and neck and salivary gland tumor biology and pathology NIDCR identified Dr. Adel El-Naggar at MDACC, a nationally and internationally recognized expert in salivary gland tumor biology and pathology, to lead the centralized biorepository. Dr. El-Naggar coordinated the effort to establish a centralized biorepository at MDACC through a consortium of satellite centers that agreed to contribute biospecimens to the biorepository. He identified a core number of experts in salivary gland pathology and biology who could help identify and catalogue biospecimens linked to diagnostic, pathologic, treatment, and outcome data. Through this consortium, the biorepository stores and catalogues fresh frozen salivary gland tumor tissues and paraffin blocks (with matched serum, saliva, lymphocytes, if applicable), as well as associated clinical data. It is anticipated that access to information on biospecimens and associated clinical data will be facilitated through a web-based electronic interface that is searchable online.

唾液腺肿瘤是罕见的肿瘤，在美国，每年约3,300例新病例。虽然手术是这些肿瘤治疗的主要方式，但晚期无法切除的原发性，复发性和转移性肿瘤通常是致命的。重要的是要注意，唾液腺恶性肿瘤的总体事件模仿了慢性心肌性白血病（CML），但CML的联邦和私人研究企业远远超过了唾液腺肿瘤的企业。结果，在该领域工作的研究人员相对较少，并且尚未建立大量研究工具供研究工具进行此类研究。 2006年10月，NCI和NIDCR召集了关于生物学和治疗恶性唾液腺肿瘤的第一个研讨会。更重要的是，研讨会表明，诸如组织标本，细胞系和动物模型之类的研究工具很少有助于促进该领域的基本和翻译研究。此外，缺乏对壁外社区可用的这些资源进行分类和收集这些资源的集中式努力。 In an effort to advance basic and translated research in this field and ultimately improve public health, NIDCR led the effort to support the establishment of a centralized biorepository at an academic institution with known expertise in head and neck and salivary gland tumor biology and pathology NIDCR identified Dr. Adel El-Naggar at MDACC, a nationally and internationally recognized expert in salivary gland tumor biology and pathology, to lead the centralized生物座席。 El-Naggar博士协调了通过卫星中心的财团在MDACC建立集中式生物座席的努力，该联盟同意为生物座位贡献生物测量。他确定了唾液腺病理学和生物学方面的核心数量，他们可以帮助识别和分类与诊断，病理，治疗和结果数据相关的生物测量。通过该财团，生物储物存储和目录新鲜冷冻的唾液腺肿瘤组织和石蜡块（如果适用，则具有匹配的血清，唾液，淋巴细胞），以及相关的临床数据。预计将通过可在线搜索的基于Web的电子界面来准备有关生物测量信息的访问和相关的临床数据。