Identifying the relationship between biochemical markers and healing in chronic leg ulcers treated with compression

慢性腿部溃疡是1 - 3%的60岁以上年龄组的疼痛、不动和生活质量下降的重要原因。这种情况很难治愈，通常会成为一个长期的问题，每年花费澳大利亚医疗保健系统超过5亿澳元。社区的额外成本包括生产力的损失和行动不便者所需的社会支助系统。由于65岁以上的人口预计在今后几十年内将翻一番，这一问题将变得日益严重。大多数慢性腿部溃疡是由静脉疾病引起的，加压绷带疗法是公认的标准治疗方法。然而，关于与压迫治疗相关的细胞反应以及它们如何促进伤口愈合的信息很少。本文提出的项目将研究细胞对压缩的反应，并研究这些细胞反应与伤口愈合之间的关系。从研究中获得的知识将为改进促进伤口愈合的技术、提高溃疡愈合率、伤口护理治疗的知情决策、提高生活质量和降低医疗保健成本提供有价值的信息。

Chronic leg ulcers are a significant cause of pain, immobility and decreased quality of life for 1 - 3% of the over 60 years age group. The condition is difficult to heal and commonly becomes a long term problem, costing the Australian health care system over $500 million - year. Additional costs to the community include loss of productivity and social support systems necessary for people with limited mobility. As the number of people aged over 65 years is expected to double in the next few decades, this problem will become increasingly significant. Most chronic leg ulcers are caused by venous disease, and compression bandage therapy is the accepted standard treatment. However, there is little information available on the cellular responses associated with compression treatment and how they promote wound healing. The project proposed here will examine the cellular responses to compression and investigate the relationships between these cellular responses and wound healing. Knowledge gained from the study will provide valuable information for improved techniques to promote wound healing, improved ulcer healing rates, informed decisions on wound care treatment, improved qualtiy of life and reduced health care costs.