Biomedical Research Core Center (P30) on Fetal Programming

描述（由申请人提供）：这是一份NIH P30生物医学研究核心中心申请（RFA-OD-09-005），内容为肥胖诱导心血管疾病发展中的胎儿编程。该请求是为了支持工资和启动费用招聘一名新的研究员，任命在营养科学研究生中心（GCNS），多学科研究和研究生课程内的医学院。通过饮食操纵作为促进成年后代肥胖和心血管疾病的机制的胎儿编程研究领域将补充和扩展NIH资助的肥胖和心血管疾病生物医学研究卓越中心（COBRE）。专门的研究核心，广泛的大学核心设施，并建立了指导机制，以促进在研究领域内对R 01竞争力的独立研究计划的发展。新招聘的教师将被分配到GCNS高度协作环境中的专用研究空间，可用于分析测量，组织病理学，血压无线遥测测量和小鼠全身代谢的常用设备和专业核心。目标研究领域补充和扩展了目前专注于确定成年人饮食诱导肥胖与心血管疾病发展相关机制的研究。在这个姐妹P30中心，新的教职员工将通过怀孕期间的饮食控制来检查胎儿编程对成年后代肥胖和心血管疾病发展的影响。鉴于美国肥胖症的患病率日益增加，重要的是要确定母亲肥胖的影响，通过消费西方饮食，对后代的疾病发展。此外，这些姐妹中心通过对比肥胖在成人发病肥胖引起的心血管疾病的发展过程中的影响，跨越了当前研究的广度。我们将利用我们现有的指导优势和我们在研究的定义领域内的重点研究核心，以确保新的研究人员开发具有临床意义的独立研究项目，以实现NIH HLBI的使命。

DESCRIPTION (provided by applicant): This is a NIH P30 Biomedical Research Core Center Application (RFA-OD-09-005) on Fetal Programming in the Development of Obesity-induced Cardiovascular Diseases. The request is for support of salary and start-up costs for recruit of one new investigator for appointment within the Graduate Center for Nutritional Sciences (GCNS), a multidisciplinary research and graduate program within the College of Medicine. The research area of fetal programming through dietary manipulation as a mechanism promoting obesity and cardiovascular disease in adult offspring will complement and extend an NIH funded Center of Biomedical Research Excellence (COBRE) on obesity and cardiovascular diseases. Specialized research cores, extensive University Core Facilities, and established mentoring mechanisms are in place to promote development of an independent research program towards R01 competitiveness within the research area. The new faculty recruit will be assigned dedicated research space within the highly collaborative environment of the GCNS, with availability to common use equipment and specialized cores for analytical measurements, tissue pathology, radiotelemetry measurement of blood pressure, and whole body metabolism in mice. The targeted research area complements and extends studies currently focused on identification of mechanisms linking diet-induced obesity in adults in the development of cardiovascular disease. In this sister P30 Center, new faculty recruits will examine effects of fetal programming through dietary manipulation during pregnancy on the development of obesity and cardiovascular diseases in adult offspring. Given the increasing prevalence of obesity in the US, it is important to identify the impact of maternal obesity, through consumption of a western diet, on disease development in offspring. Moreover, these sister Centers span the breadth of current research by contrasting effects of obesity during development from adult onset obesity-induced cardiovascular disease. We will use our existing strengths in mentoring and our focused research cores within the defined area of study to assure that new investigators develop independent research programs of clinical significance to the missions of NIH HLBI.