Regenerative Biology Center at the MBL

MBL 再生生物学中心

• 批准号: 7859421
• 负责人: Gary G Borisy
• 金额: $ 40.13万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859421
• 关键词: Aging; Area; Award; Be++ element; Beryllium; Biodiversity; Biological; Biological Models; Biology; Biomedical Research; Cells; Center Core Grants; Commit; Country; Elements; Embryology; Equipment; Faculty; Funding; Genome; Genomics; Grant; Health; Home environment; Human; Image; Individual; Informatics; Invertebrates; Investments; Knowledge; Laboratories; Laboratory Scientists; Marine Invertebrates; Marines; Massachusetts; Medical; Medical center; Modeling; Mus; National Center for Research Resources; Natural regeneration; Neurobiology; Organ; Organism; Physiology; Positioning Attribute; Primates; Process; Recruitment Activity; Regenerative Medicine; Regulator Genes; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Scientist; Senior Scientist; System; Time; Tissues; Training Programs; Universities; Wages; Wood material; Work; Xenopus; marine organism; member; multidisciplinary; professor; programs; regenerative; repaired; stem cell biology

DESCRIPTION (provided by applicant): The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, proposes to launch a high-impact, multidisciplinary and unique initiative in regenerative and stem cell biology drawing upon the special advantages of marine invertebrates. Regenerative and stem cell biology is being recognized in medical centers across the country as a critical area of science for establishing the potential of regenerative medicine. In this emerging field, scientists seek to define and understand the natural processes by which damaged or aging tissues and organs can regenerate or be repaired, and to apply that knowledge to developing medical therapies. Although mammalian systems are unquestionably of direct relevance and great importance for human health, non-mammalian models including bacterial, fungal, invertebrate and vertebrate systems have contributed enormously to our understanding of the fundamental cell and tissue biology that underpin medical advances. Among possible model systems, marine invertebrates and lower vertebrate organisms hold great promise specifically as research models for regeneration, particularly as the field progresses in decoding their genomes. The MBL has invested in the cognate areas of cellular dynamics, imaging, genomics, marine husbandry and biodiversity informatics. The MBL is renowned for its advanced research training programs in physiology, neurobiology, embryology and gene regulatory networks. We believe the physical and intellectual infrastructure investments already made at the MBL pre- adapt it to launch a new initiative in Regenerative Biology. The missing element is to establish a critical mass of individuals focused on this area. The P30 program support is vital for recruiting two individuals who, with existing MBL scientists, would provide the critical mass for establishing the Center. We believe that the time is ripe to exploit the special experimental potential of marine organisms and that the MBL is uniquely pre- adapted to serve as the home for a new Center for Regenerative Biology.

描述（由申请人提供）：位于马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）提议利用海洋无脊椎动物的特殊优势，在再生和干细胞生物学方面开展一项高影响力、多学科和独特的倡议。再生和干细胞生物学在全国各地的医学中心被认为是确立再生医学潜力的一个关键科学领域。在这一新兴领域，科学家们试图定义和理解受损或老化的组织和器官再生或修复的自然过程，并将这些知识应用于开发医学疗法。尽管哺乳动物系统无疑与人类健康有着直接的关系，而且对人类健康非常重要，但包括细菌、真菌、无脊椎动物和脊椎动物系统在内的非哺乳动物模型对我们理解基础细胞和组织生物学做出了巨大贡献，而这些细胞和组织生物学是医学进步的基础。在可能的模型系统中，海洋无脊椎动物和低等脊椎动物生物具有很大的前景，特别是作为再生研究模型，特别是随着该领域在解码其基因组方面的进展。MBL在细胞动力学、成像、基因组学、海洋畜牧业和生物多样性信息学等相关领域进行了投资。MBL以其在生理学、神经生物学、胚胎学和基因调控网络方面的先进研究培训项目而闻名。我们相信，已经在MBL进行的物质和智力基础设施投资已经使它适应了再生生物学的新举措。缺少的要素是建立一个临界质量的个人专注于这个领域。P30项目的支持对于招募两名个人至关重要，他们将与现有的MBL科学家一起为建立中心提供关键的质量。我们相信，利用海洋生物的特殊实验潜力的时机已经成熟，而且MBL经过了独特的预适应，可以作为一个新的再生生物学中心的所在地。