Regenerative Biology Center at the MBL

MBL 再生生物学中心

• 批准号: 7944074
• 负责人: Gary G Borisy
• 金额: $ 40.13万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944074
• 关键词: Aging; Area; Award; Be++ element; Beryllium; Biodiversity; Biological; Biological Models; Biology; Biomedical Research; Cells; Center Core Grants; Commit; Country; Elements; Embryology; Equipment; Faculty; Funding; Genome; Genomics; Grant; Health; Home environment; Human; Image; Individual; Informatics; Invertebrates; Investments; Knowledge; Laboratories; Laboratory Scientists; Marine Invertebrates; Marines; Massachusetts; Medical; Medical center; Modeling; Mus; National Center for Research Resources; Natural regeneration; Neurobiology; Organ; Organism; Physiology; Positioning Attribute; Primates; Process; Recruitment Activity; Regenerative Medicine; Regulator Genes; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Scientist; Senior Scientist; System; Time; Tissues; Training Programs; Universities; Wages; Wood material; Work; Xenopus; marine organism; member; multidisciplinary; professor; programs; regenerative; repaired; stem cell biology

DESCRIPTION (provided by applicant): The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, proposes to launch a high-impact, multidisciplinary and unique initiative in regenerative and stem cell biology drawing upon the special advantages of marine invertebrates. Regenerative and stem cell biology is being recognized in medical centers across the country as a critical area of science for establishing the potential of regenerative medicine. In this emerging field, scientists seek to define and understand the natural processes by which damaged or aging tissues and organs can regenerate or be repaired, and to apply that knowledge to developing medical therapies. Although mammalian systems are unquestionably of direct relevance and great importance for human health, non-mammalian models including bacterial, fungal, invertebrate and vertebrate systems have contributed enormously to our understanding of the fundamental cell and tissue biology that underpin medical advances. Among possible model systems, marine invertebrates and lower vertebrate organisms hold great promise specifically as research models for regeneration, particularly as the field progresses in decoding their genomes. The MBL has invested in the cognate areas of cellular dynamics, imaging, genomics, marine husbandry and biodiversity informatics. The MBL is renowned for its advanced research training programs in physiology, neurobiology, embryology and gene regulatory networks. We believe the physical and intellectual infrastructure investments already made at the MBL pre- adapt it to launch a new initiative in Regenerative Biology. The missing element is to establish a critical mass of individuals focused on this area. The P30 program support is vital for recruiting two individuals who, with existing MBL scientists, would provide the critical mass for establishing the Center. We believe that the time is ripe to exploit the special experimental potential of marine organisms and that the MBL is uniquely pre- adapted to serve as the home for a new Center for Regenerative Biology.

描述（由申请人提供）：马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）提议发起一项高影响力，多学科和独特的倡议，从而利用海洋无脊椎动物的特殊优势来创建再生和干细胞生物学。在全国各地的医疗中心被认为是建立再生医学潜力的关键科学领域。在这个新兴领域，科学家试图定义和了解受损或老化的组织和器官可以再生或修复的自然过程，并将这些知识应用于开发的医疗疗法。尽管毫无疑问，哺乳动物系统具有直接相关性和对人类健康的重要性，但包括细菌，真菌，无脊椎动物和脊椎动物系统在内的非哺乳动物模型为我们对基本细胞和组织生物学的理解做出了巨大贡献，这些细胞和组织生物学基于医学的进步。在可能的模型系统中，海洋无脊椎动物和下部脊椎动物有很大的希望，特别是作为再生的研究模型，尤其是随着田间在解码其基因组时的发展。 MBL已投资于细胞动态，成像，基因组学，海洋饲养和生物多样性信息学的同源领域。 MBL以其生理学，神经生物学，胚胎学和基因调节网络的高级研究培训计划而闻名。我们认为，MBL预先对其进行了体育和智力基础设施投资，可以使其适应新的生物学倡议。缺失的要素是建立关注这一领域的临界人群。 P30计划的支持对于招募两个人，他们与现有MBL科学家一起为建立中心提供关键群众至关重要。我们认为，利用海洋生物的特殊实验潜力的时机已经成熟，并且MBL是独特的，可以作为新的再生生物学中心的家园。