EFFICACY OF INHALED CANNABIS FOR THE TREATMENT OF PAINFUL DIABETIC NEUROPATHY

吸入大麻治疗疼痛性糖尿病神经病的功效

• 批准号: 7950969
• 负责人: MARK S WALLACE
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950969
• 关键词: Affect; Breathing; Cannabis; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Descriptor; Diabetic Neuralgia; Dose; Enrollment; Funding; Grant; Institution; Measures; Pain; Patients; Peripheral Nervous System Diseases; Placebos; Research; Research Personnel; Resources; Source; Therapeutic Agents; United States National Institutes of Health; cognitive function; diabetic; painful neuropathy; spontaneous pain

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, there is a significant need for more therapeutic agents for the treatment of neuropathic pain. We propose to use painful diabetic peripheral neuropathy (DPN) patients to study the efficacy of inhaled cannabis on neuropathic pain. We will enroll 20 subjects with each subject acting as their own control (receiving both placebo and three doses of inhaled cannabis (low, medium and high) in random order each separated by at least two weeks. HYPOTHESES: 1) Cannabis will result in a dose dependent decrease in the spontaneous pain and qualitative pain descriptors. 2) Pain relief will occur at cannabis doses that do not significantly affect cognitive function. 3) Cannabis will decrease experimental pain as measured by the BTS. The effect on the BTS will correlate with the decrease in spontaneous pain of DPN.

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