EFFICACY OF INHALED CANNABIS FOR THE TREATMENT OF PAINFUL DIABETIC NEUROPATHY

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目前，非常需要更多的治疗剂来治疗神经性疼痛。我们建议使用疼痛的糖尿病周围神经病变（DPN）患者来研究吸入大麻对神经性疼痛的功效。我们将招募 20 名受试者，每名受试者作为自己的对照（按随机顺序接受安慰剂和三剂吸入大麻（低、中和高剂量），每剂间隔至少两周。 假设： 1) 大麻会导致自发性疼痛和定性疼痛描述符的剂量依赖性减少。 2）大麻剂量会缓解疼痛，不会显着影响认知功能。 3) 根据 BTS 的测量，大麻会减少实验性疼痛。对 BTS 的影响将与 DPN 自发性疼痛的减少相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, there is a significant need for more therapeutic agents for the treatment of neuropathic pain. We propose to use painful diabetic peripheral neuropathy (DPN) patients to study the efficacy of inhaled cannabis on neuropathic pain. We will enroll 20 subjects with each subject acting as their own control (receiving both placebo and three doses of inhaled cannabis (low, medium and high) in random order each separated by at least two weeks. HYPOTHESES: 1) Cannabis will result in a dose dependent decrease in the spontaneous pain and qualitative pain descriptors. 2) Pain relief will occur at cannabis doses that do not significantly affect cognitive function. 3) Cannabis will decrease experimental pain as measured by the BTS. The effect on the BTS will correlate with the decrease in spontaneous pain of DPN.