EFFICACY OF INHALED CANNABIS FOR THE TREATMENT OF PAINFUL DIABETIC NEUROPATHY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 目前，对于用于治疗神经性疼痛的更多治疗剂存在显著需求。我们建议使用疼痛的糖尿病周围神经病变（DPN）患者研究吸入大麻对神经性疼痛的疗效。我们将招募20名受试者，每名受试者作为自己的对照组（接受安慰剂和三种剂量的吸入性大麻（低，中和高），随机顺序，每种剂量间隔至少两周。 假设： 1)大麻将导致自发性疼痛和定性疼痛描述符的剂量依赖性降低。 2)疼痛缓解将发生在大麻剂量不显着影响认知功能。 3)大麻将减少BTS测量的实验性疼痛。对BTS的影响将与DPN自发性疼痛的减少相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, there is a significant need for more therapeutic agents for the treatment of neuropathic pain. We propose to use painful diabetic peripheral neuropathy (DPN) patients to study the efficacy of inhaled cannabis on neuropathic pain. We will enroll 20 subjects with each subject acting as their own control (receiving both placebo and three doses of inhaled cannabis (low, medium and high) in random order each separated by at least two weeks. HYPOTHESES: 1) Cannabis will result in a dose dependent decrease in the spontaneous pain and qualitative pain descriptors. 2) Pain relief will occur at cannabis doses that do not significantly affect cognitive function. 3) Cannabis will decrease experimental pain as measured by the BTS. The effect on the BTS will correlate with the decrease in spontaneous pain of DPN.