ATORVASTATIN FOR TREATMENT OF PCOS WOMEN WITH ELEVATED LDL CHOLESTEROL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该建议的总体假设是，异常脂质水平可能在多囊卵巢综合征（PCOS）的发展中发挥更重要的作用，因此，使脂质水平正常化的干预措施可能会改善血管功能，以及改善高雄激素血症和胰岛素敏感性，这可能会降低PCOS女性患心血管疾病的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this proposal is that abnormal lipid levels may play a more central role in the development of Polycystic Ovary Syndrome (PCOS), and therefore, interventions to normalize lipid levels may result in improved vascular function, as well as, improved hyperandrogenemia and insulin sensitivity which may lower the risk for cardiovascular disease in women with PCOS.