DEVELOPMENT OF A SCREENING TEST FOR ENDOMETRIAL HYPERPLASIA IN AN AT RISK COHORT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目的是确定超声作为子宫内膜增生和子宫内膜癌的筛查试验在“高危”人群中的实用性。 我们假设子宫内膜厚度是绝经后女性代谢综合征（糖尿病和/或胰岛素抵抗、高血压和肥胖）患者子宫内膜增生的重要预测因子。 子宫内膜癌是一种研究不足的癌症，不成比例地影响宾夕法尼亚州的妇女。 无论结果如何，这项研究都将提供益处，因为它将是第一个在无症状人群中进行的前瞻性设计的筛选试验。 在缺乏数据的情况下，不应假设筛查或不筛查像子宫内膜癌这样常见和病态的疾病的效用。 我们希望能够填补目前妇科相关癌症筛查的空白。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our objective is to identify the utility of ultrasound as a screening test for endometrial hyperplasia and cancer in an "at risk" cohort. We hypothesize that endometrial thickness will be a significant predictor of endometrial hyperplasia in a postmenopausal female population with the metabolic syndrome: diabetes and/or insulin resistance, hypertension, and obesity. Endometrial carcinoma is an understudied cancer that disproportionately affects the women of Pennsylvania. This study will provide benefit regardless of its outcome, because it will be the first prospectively designed screening trial in an asymptomatic population. Assumptions made about the utility of screening or not screening for a disease as common and as morbid as endometrial cancer should not be made in the absence of data. We hope that we will be able to fill the current void in screening for gynecologic related cancers.