HYPERANDROGENISM AND INSULIN RESISTANCE IN THE ONTOGENY OF PCOS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项病例/对照纵向研究，将患有多囊卵巢综合征的妇女的子女与非多囊卵巢综合征妇女的子女进行比较，以检验存在与这种综合征相关的高雄激素血症的可传播等位基因的假设。 患有多囊卵巢综合征的妇女的孩子可能比没有多囊卵巢综合征的母亲的孩子更有可能受到影响，而且候选等位基因增加了风险。我们假设患有多囊卵巢综合征的妇女的女儿可能会患上高雄激素血症，并且候选等位基因的传播将预测风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a case/control longitudinal study of children of women with PCOS compared to children of women without PCOS to test the hypothesis that there is a transmissible allele that confers hyperandrogenism associated with this syndrome. It is likely that children of women with PCOS are more likely to be affected than children of mothers without PCOS, and further that the candidate allele confers increased risk. We hypothesizes that daughters of women with PCOS are likely to develop hyperandrogenism, and that transmission of a candidate allele will predict risk.