HYPERANDROGENISM AND INSULIN RESISTANCE IN THE ONTOGENY OF PCOS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这是一项病例/对照纵向研究，比较了PCOS妇女的子女与非PCOS妇女的子女，以检验存在一个可传递的等位基因赋予与该综合征相关的高雄激素血症的假设。 有可能患有PCOS的妇女的孩子比没有PCOS的母亲的孩子更容易受到影响，而且候选等位基因赋予增加的风险。 我们假设多囊卵巢综合征妇女的女儿可能发展为高雄激素血症，并且候选等位基因的传递将预测风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a case/control longitudinal study of children of women with PCOS compared to children of women without PCOS to test the hypothesis that there is a transmissible allele that confers hyperandrogenism associated with this syndrome. It is likely that children of women with PCOS are more likely to be affected than children of mothers without PCOS, and further that the candidate allele confers increased risk. We hypothesizes that daughters of women with PCOS are likely to develop hyperandrogenism, and that transmission of a candidate allele will predict risk.