MAGNESIUM SUPPLEMENTS

镁补充剂

• 批准号: 7951570
• 负责人: Simin Liu
• 金额: $ 1.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951570
• 关键词: Blood; C-reactive protein; Calcium; Cholesterol; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; E-Selectin; Electrolytes; Estradiol; Fibrinogen; Funding; Gene Expression Profile; Gene Expression Profiling; Glucose; Gonadal Steroid Hormones; Grant; High Density Lipoprotein Cholesterol; Institution; Intercellular Adhesion Molecules; LDL Cholesterol Lipoproteins; Magnesium; Metabolic syndrome; Microarray Analysis; Patients; Placebo Control; Plasma; Plasminogen Activator Inhibitor 1; Potassium; Randomized; Research; Research Personnel; Resources; Saliva; Serum; Sex Hormone-Binding Globulin; Source; Supplementation; TNF gene; Testosterone; Triglycerides; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; United States National Institutes of Health; Vascular Cell Adhesion Molecule-1; Whole Blood; blood lipid; diabetic; inflammatory marker; insulin sensitivity; pilot trial; protein E; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS We propose to conduct a randomized, placebo-controlled pilot trial in patients with metabolic syndrome with the primary aim of studying the effect of magnesium supplementation on various traditional and non-traditional markers of inflammation and diabetic status which includes: 1. Insulin sensitivity and glucose response. 2. Blood lipids including total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides (TG). 3. Blood electrolyte status including magnesium, calcium, and potassium. 4. Plasma inflammatory markers, sex hormones and endothelial markers such as C-reactive protein (CRP), E-selectin, intercellular adhesion molecule (ICAM), Vascular cell adhesion molecule (VCAM), Tumor necrosis factor ?-1 (TNF- ?), interlukin-6 (IL-6), testosterone, estradiol, sex hormone binding globulin, plasminogen activator inhibitor-1 (PAI-1) and fibrinogen. 5. Whole blood gene expression profiling using microarray technology. 6. Serum gene expression profiling using microarray technology. 7. Saliva gene expression profiling using microarray technology. Our secondary aim is to compare the correlation/reliability of transcriptome profiling assessed in saliva versus whole blood and serum.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体目标 我们建议对代谢综合征患者进行随机的，安慰剂对照的试验试验，其主要目的是研究补充镁对炎症和糖尿病状态的各种传统和非传统标志物的影响，其中包括： 1。胰岛素敏感性和葡萄糖反应。 2。血脂，包括总胆固醇，低密度脂蛋白胆固醇（LDL），高密度脂蛋白胆固醇（HDL）和甘油三酸酯（TG）。 3。血液电解质状态，包括镁，钙和钾。 4。血浆炎症标志物，性激素和内皮标志物，例如C反应蛋白（CRP），E-选择素，细胞间粘附分子（ICAM），血管细胞粘附分子（VCAM），肿瘤坏死因子？结合球蛋白，纤溶酶原激活剂1（PAI-1）和纤维蛋白原。 5。使用微阵列技术进行全血基因表达分析。 6。使用微阵列技术进行血清基因表达分析。 7。使用微阵列技术进行唾液基因表达分析。 我们的次要目的是比较在唾液与全血和血清中评估的转录组分析的相关性/可靠性。