NEURAL SYSTEMS, INHIBITORY CONTROL, AND METHAMPHETAMINE DEPENDENCE (IRB #05-0

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 本项目旨在阐明MA滥用者在抑制控制的实验室测试中反应抑制缺陷的神经生物学基础。其目的是绘制MA滥用者的大脑功能异常图，通过fMRI测量的激活来索引。使用[18F]FolyPride的PET扫描将被用于检测大脑纹状体外区域的D2/D3多巴胺受体。该项目还旨在测试一种潜在的药物，该药物已显示出在改善人类受试者抑制控制方面的前景。所获得的知识可能最终支持针对MA依赖这一疾病症状的循证治疗干预措施的开发，这是一个具有巨大全球影响的药物滥用问题。 目的1.确定MA依赖受试者抑制控制缺陷的神经底物(通过反应抑制和转换SET的能力来指示)。使用从这项研究的安慰剂条件下收集的数据(见目标3)，我们将在MA依赖和对照受试者中将fMRI与停止信号任务和概率反转学习任务的表现配对。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: This project aims to clarify the neurobiological basis for deficits in response inhibition in laboratory tests of inhibitory control in MA abusers. The objective is to map abnormalities in brain function in MA abusers, as indexed by activations measured by fMRI. PET scans, using [18F]fallypride, will be utilized to assay D2/D3 dopamine receptors in extrastriatal regions of the brain. This project also aims to test a potential medication that has shown promise in improving inhibitory control in human subjects. The knowledge gained may ultimately support evidence-based development of therapeutic interventions targeting this disease symptom in MA dependence, a drug abuse problem that has tremendous global impact. Aim 1. Identify neural substrates of inhibitory control deficits (as indicated by measures of response inhibition and ability to shift set) in MA-dependent subjects. Using data collected from the placebo condition of this study (see Aim 3), we will pair fMRI with performance on a Stop-Signal Task and a Probabilistic Reversal Learning Task in MA-dependent and control subjects.